Hypoxia. 5. Hypoxia and Hematopoiesis

Overview

Journal Am J Physiol Cell Physiol

Publisher American Physiological Society

Specialties Cell Biology
Physiology

Date 2011 Mar 4

PMID 21368293

Citations 27

Authors

Donghoon Yoon

Prem Ponka

Josef T Prchal

Affiliations

Soon will be listed here.

Abstract

Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia. HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery.

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