Cardiometabolic Plasticity in Response to a Short-term Diet and Exercise Intervention in Young Hispanic and NonHispanic White Adults

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2011 Mar 3

PMID 21364957

Citations 1

Authors

Stacy L Schmidt

Matthew S Hickey

Kathryn M Koblenz

Holly Klamer

Maria F Botero

Kyle T Pfaffenbach

Michael J Pagliassotti

Christopher L Melby

Affiliations

Soon will be listed here.

Abstract

Background: Young adult Mexican Americans (MA) exhibit lower insulin sensitivity (Si) than nonHispanic whites (NHW), even when controlling for fitness and adiposity. It is unclear if MA are as responsive to the same lifestyle intervention as NHW.

Objective: We developed a model to examine cardiometabolic plasticity (i.e., changes in Si and plasma lipids) in MA compared to NHW adults in response to a diet-exercise intervention.

Design: Sedentary subjects (20 NHW: 11F, 9M, 23.0 y, 25.5 kg/m(2); 17 MA: 13F, 4M, 22.7 y, 25.4 kg/m(2)) consumed their habitual diets and remained sedentary for 7 days, after which fasting blood samples were obtained, and a 3-h intravenous glucose tolerance test (IVGTT) was performed with the insulin area under the curve (IAUC) used to estimate Si. Subjects then completed a 7-day diet/exercise intervention (diet: low saturated fat, low added sugar, high fiber; exercise: cycling, six total sessions lasting 40-45 min/session at 65% VO(2) max). Pre-intervention tests were repeated.

Results: Pre intervention IAUC was 28% higher (p<0.05) in MA (IAUC pre = 2298 µU*180 min/mL) than in NHW (IAUC = 1795 µU*180 min/mL). Following the intervention, there was a significant reduction in IAUC in MA (29%) and NHW (32%), however, the IAUC remained higher (p<0.05) for MA (post = 1635 µU*180 min/mL) than for NHW (post = 1211 µU*180 min/mL). Pre test plasma lipids were not different in MA compared to NHW. Plasma cholesterol and TG concentrations significantly improved in both groups, but concentrations of low density lipoprotein-cholesterol and small dense LDL particles significantly improved only in the NHW.

Conclusion: With a short-term diet-exercise intervention, the magnitude of improvements in Si and serum cholesterol and TG in Hispanics are similar to those in NHW. However, because at the outset MA were less insulin sensitive compared to NHW, within the short timeframe studied the ethnic gap in insulin sensitivity remained.

Citing Articles

Physical activity, sedentary behaviors and the incidence of type 2 diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis (MESA).

Joseph J, Echouffo-Tcheugui J, Golden S, Chen H, Jenny N, Carnethon M BMJ Open Diabetes Res Care. 2016; 4(1):e000185.

PMID: 27403323 PMC: 4932325. DOI: 10.1136/bmjdrc-2015-000185.

References

Corpeleijn E, van der Kallen C, Kruijshoop M, Magagnin M, de Bruin T, Feskens E . Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance. Diabet Med. 2006; 23(8):907-11. DOI: 10.1111/j.1464-5491.2006.01888.x. View

Li C, Ford E, McGuire L, Mokdad A, Little R, Reaven G . Trends in hyperinsulinemia among nondiabetic adults in the U.S. Diabetes Care. 2006; 29(11):2396-402. DOI: 10.2337/dc06-0289. View

Tusie Luna M . Genes and type 2 diabetes mellitus. Arch Med Res. 2005; 36(3):210-22. DOI: 10.1016/j.arcmed.2005.03.004. View

WEIR J . New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol. 1949; 109(1-2):1-9. PMC: 1392602. DOI: 10.1113/jphysiol.1949.sp004363. View

Srinivasan S, Frontini M, Berenson G . Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Bogalusa Heart Study. Metabolism. 2003; 52(4):443-50; discussion 451-3. DOI: 10.1053/meta.2003.50065. View

Frosig C, Richter E . Improved insulin sensitivity after exercise: focus on insulin signaling. Obesity (Silver Spring). 2009; 17 Suppl 3:S15-20. DOI: 10.1038/oby.2009.383. View

Kishimoto H, Taniguchi A, Fukushima M, Sakai M, Tokuyama K, Oguma T . Effect of short-term low-intensity exercise on insulin sensitivity, insulin secretion, and glucose and lipid metabolism in non-obese Japanese type 2 diabetic patients. Horm Metab Res. 2002; 34(1):27-31. DOI: 10.1055/s-2002-19963. View

Knowler W, Barrett-Connor E, Fowler S, Hamman R, Lachin J, Walker E . Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346(6):393-403. PMC: 1370926. DOI: 10.1056/NEJMoa012512. View

Kraniou G, Cameron-Smith D, Hargreaves M . Effect of short-term training on GLUT-4 mRNA and protein expression in human skeletal muscle. Exp Physiol. 2004; 89(5):559-63. DOI: 10.1113/expphysiol.2004.027409. View

10.

Duncan G, Perri M, Theriaque D, Hutson A, Eckel R, Stacpoole P . Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care. 2003; 26(3):557-62. DOI: 10.2337/diacare.26.3.557. View

11.

Houmard J, Hickey M, Tyndall G, Gavigan K, Dohm G . Seven days of exercise increase GLUT-4 protein content in human skeletal muscle. J Appl Physiol (1985). 1995; 79(6):1936-8. DOI: 10.1152/jappl.1995.79.6.1936. View

12.

Olefsky J, Farquhar J, Reaven G . Reappraisal of the role of insulin in hypertriglyceridemia. Am J Med. 1974; 57(4):551-60. DOI: 10.1016/0002-9343(74)90006-0. View

13.

Dixon L, Sundquist J, Winkleby M . Differences in energy, nutrient, and food intakes in a US sample of Mexican-American women and men: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol. 2000; 152(6):548-57. DOI: 10.1093/aje/152.6.548. View

14.

Cruz M, Weigensberg M, Huang T, Ball G, Shaibi G, Goran M . The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab. 2004; 89(1):108-13. DOI: 10.1210/jc.2003-031188. View

15.

Rogers M, Yamamoto C, King D, Hagberg J, Ehsani A, Holloszy J . Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM. Diabetes Care. 1988; 11(8):613-8. DOI: 10.2337/diacare.11.8.613. View

16.

Ford E, Giles W, Dietz W . Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002; 287(3):356-9. DOI: 10.1001/jama.287.3.356. View

17.

Haskell W . The influence of exercise on the concentrations of triglyceride and cholesterol in human plasma. Exerc Sport Sci Rev. 1984; 12:205-44. View

18.

Houmard J, Shaw C, Hickey M, Tanner C . Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle. Am J Physiol. 1999; 277(6):E1055-60. DOI: 10.1152/ajpendo.1999.277.6.E1055. View

19.

Crespo C, Smit E, Carter-Pokras O, Andersen R . Acculturation and leisure-time physical inactivity in Mexican American adults: results from NHANES III, 1988-1994. Am J Public Health. 2001; 91(8):1254-7. PMC: 1446756. DOI: 10.2105/ajph.91.8.1254. View

20.

Baier L, Permana P, Yang X, Pratley R, Hanson R, Shen G . A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest. 2000; 106(7):R69-73. PMC: 387246. DOI: 10.1172/JCI10665. View