Shift Work and Chronic Disease: the Epidemiological Evidence

Overview

Journal Occup Med (Lond)

Publisher Oxford University Press

Specialty Occupational Medicine

Date 2011 Mar 1

PMID 21355031

Citations 216

Authors

X-S Wang

M E G Armstrong

B J Cairns

T J Key

R C Travis

Affiliations

Soon will be listed here.

Abstract

Background: Shift work, including night work, has been hypothesized to increase the risk of chronic diseases, including cancer, cardiovascular disease (CVD), metabolic syndrome and diabetes. Recent reviews of evidence relating to these hypotheses have focussed on specific diseases or potential mechanisms, but no general summary of the current data on shift work and chronic disease has been published.

Methods: Systematic and critical reviews and recent original studies indexed in PubMed prior to 31 December 2009 were retrieved, aided by manual searches of reference lists. The main conclusions from reviews and principle results from recent studies are presented in text and tables.

Results: Published evidence is suggestive but not conclusive for an adverse association between night work and breast cancer but limited and inconsistent for cancers at other sites and all cancers combined. Findings on shift work, in relation to risks of CVD, metabolic syndrome and diabetes are also suggestive but not conclusive for an adverse relationship.

Conclusions: Heterogeneity of study exposures and outcomes and emphasis on positive but non-significant results make it difficult to draw general conclusions. Further data are needed for additional disease endpoints and study populations.

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References

Stevens R . Light-at-night, circadian disruption and breast cancer: assessment of existing evidence. Int J Epidemiol. 2009; 38(4):963-70. PMC: 2734067. DOI: 10.1093/ije/dyp178. View

Kubo T, Ozasa K, Mikami K, Wakai K, Fujino Y, Watanabe Y . Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study. Am J Epidemiol. 2006; 164(6):549-55. DOI: 10.1093/aje/kwj232. View

Mikuni E, Ohoshi T, Hayashi K, Miyamura K . Glucose intolerance in an employed population. Tohoku J Exp Med. 1983; 141 Suppl:251-6. DOI: 10.1620/tjem.141.suppl_251. View

Karlsson B, Alfredsson L, Knutsson A, Andersson E, Toren K . Total mortality and cause-specific mortality of Swedish shift- and dayworkers in the pulp and paper industry in 1952-2001. Scand J Work Environ Health. 2005; 31(1):30-5. DOI: 10.5271/sjweh.845. View

De Bacquer D, Van Risseghem M, Clays E, Kittel F, De Backer G, Braeckman L . Rotating shift work and the metabolic syndrome: a prospective study. Int J Epidemiol. 2009; 38(3):848-54. DOI: 10.1093/ije/dyn360. View

Kroenke C, Spiegelman D, Manson J, Schernhammer E, Colditz G, Kawachi I . Work characteristics and incidence of type 2 diabetes in women. Am J Epidemiol. 2006; 165(2):175-83. DOI: 10.1093/aje/kwj355. View

. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002; 106(25):3143-421. View

Knutsson A, Akerstedt T, Jonsson B, Orth-Gomer K . Increased risk of ischaemic heart disease in shift workers. Lancet. 1986; 2(8498):89-92. DOI: 10.1016/s0140-6736(86)91619-3. View

Kakizaki M, Inoue K, Kuriyama S, Sone T, Matsuda-Ohmori K, Nakaya N . Sleep duration and the risk of prostate cancer: the Ohsaki Cohort Study. Br J Cancer. 2008; 99(1):176-8. PMC: 2453016. DOI: 10.1038/sj.bjc.6604425. View

10.

Kakizaki M, Kuriyama S, Sone T, Ohmori-Matsuda K, Hozawa A, Nakaya N . Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study. Br J Cancer. 2008; 99(9):1502-5. PMC: 2579702. DOI: 10.1038/sj.bjc.6604684. View

11.

Schernhammer E, Kroenke C, Laden F, Hankinson S . Night work and risk of breast cancer. Epidemiology. 2005; 17(1):108-11. DOI: 10.1097/01.ede.0000190539.03500.c1. View

12.

Waage S, Moen B, Pallesen S, Eriksen H, Ursin H, Akerstedt T . Shift work disorder among oil rig workers in the North Sea. Sleep. 2009; 32(4):558-65. PMC: 2663659. DOI: 10.1093/sleep/32.4.558. View

13.

Haupt C, Alte D, Dorr M, Robinson D, Felix S, John U . The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population. Atherosclerosis. 2008; 201(1):205-11. DOI: 10.1016/j.atherosclerosis.2007.12.059. View

14.

Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V . Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol. 2009; 8(12):1065-6. DOI: 10.1016/S1470-2045(07)70373-X. View

15.

Tynes T, Hannevik M, Andersen A, Vistnes A, Haldorsen T . Incidence of breast cancer in Norwegian female radio and telegraph operators. Cancer Causes Control. 1996; 7(2):197-204. DOI: 10.1007/BF00051295. View

16.

Violanti J, Burchfiel C, Hartley T, Mnatsakanova A, Fekedulegn D, Andrew M . Atypical work hours and metabolic syndrome among police officers. Arch Environ Occup Health. 2009; 64(3):194-201. DOI: 10.1080/19338240903241259. View

17.

Ellingsen T, Bener A, Gehani A . Study of shift work and risk of coronary events. J R Soc Promot Health. 2007; 127(6):265-7. DOI: 10.1177/1466424007083702. View

18.

Schernhammer E, Berrino F, Krogh V, Secreto G, Micheli A, Venturelli E . Urinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohort. Cancer Epidemiol Biomarkers Prev. 2010; 19(3):729-37. PMC: 2837369. DOI: 10.1158/1055-9965.EPI-09-1229. View

19.

Brown D, Feskanich D, Sanchez B, Rexrode K, Schernhammer E, Lisabeth L . Rotating night shift work and the risk of ischemic stroke. Am J Epidemiol. 2009; 169(11):1370-7. PMC: 2727250. DOI: 10.1093/aje/kwp056. View

20.

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View