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Prevalence of Methicillin-resistant Staphylococcus Aureus (MRSA) in a Tertiary Care Hospital in Northern India

Overview
Journal J Lab Physicians
Specialty Pathology
Date 2011 Feb 25
PMID 21346901
Citations 18
Authors
Shilpa Arora
Pushpa Devi
Usha Arora
Bimla Devi
Affiliations
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Abstract

Aim: The emergence of Methicillin-resistant Staphylococcus aureus (MRSA) has posed a serious therapeutic challenge. We report the prevalence and antibiotic susceptibility pattern of MRSA in the hospitals attached to GMC, Amritsar, Punjab.

Materials And Methods: The study comprised of 250 coagulase-positive staphylococci (COPS) isolated from a total of 6743 clinical specimens (like pus, blood, urine, high vaginal swab, sputum, etc.) of patients admitted in hospitals attached to Government Medical College, Amritsar from January 2008-February 2009. Routine antibiotic susceptibility testing was performed and interpreted as per standard guidelines. Methicillin resistance was detected using oxacillin and cefoxitin disc diffusion method, oxacillin screen agar method, and minimum inhibitory concentration using broth macrodilution method.

Results: A total of 115 (46%) strains were found to be methicillin resistant. Multidrug resistance was observed in 73% MRSA strains. However, no strain was resistant to vancomycin.

Conclusion: Regular surveillance of hospital-associated infection and monitoring of antibiotic sensitivity pattern is required to reduce MRSA prevalence.

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References
1.
Tiwari H, Das A, Sapkota D, Sivrajan K, Pahwa V . Methicillin resistant Staphylococcus aureus: prevalence and antibiogram in a tertiary care hospital in western Nepal. J Infect Dev Ctries. 2009; 3(9):681-4. DOI: 10.3855/jidc.86. View
2.
Gupta M, Singh N, Kumar A, Kaur I . Cefoxitin disk diffusion test--better predictor of methicillin resistance in Staphylococcus aureus. Indian J Med Microbiol. 2009; 27(4):379-80. DOI: 10.4103/0255-0857.55447. View
3.
Menezes G, Harish B, Sujatha S, Vinothini K, Parija S . Emergence of vancomycin-intermediate Staphylococcus species in southern India. J Med Microbiol. 2008; 57(Pt 7):911-912. DOI: 10.1099/jmm.0.47829-0. View
4.
Rajaduraipandi K, Mani K, Panneerselvam K, Mani M, Bhaskar M, Manikandan P . Prevalence and antimicrobial susceptibility pattern of methicillin resistant Staphylococcus aureus: a multicentre study. Indian J Med Microbiol. 2006; 24(1):34-8. DOI: 10.4103/0255-0857.19892. View
5.
Vidhani S, Mehndiratta P, Mathur M . Study of methicillin resistant S. aureus (MRSA) isolates from high risk patients. Indian J Med Microbiol. 2007; 19(2):13-6. View