Cytotoxic T Cells - Stroma Interactions

Overview

Journal Bull Cancer

Publisher Elsevier

Specialty Oncology

Date 2011 Feb 23

PMID 21339092

Citations 5

Authors

Muhammad Zaeem Noman

Houssem Benlalam

Meriem Hasmim

Salem Chouaib

Affiliations

Soon will be listed here.

Abstract

The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.

Citing Articles

Decoding cancer's camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade.

Lotsberg M, Rayford A, Thiery J, Belleggia G, DMello Peters S, Lorens J Cancer Drug Resist. 2022; 3(4):832-853.

PMID: 35582229 PMC: 8992561. DOI: 10.20517/cdr.2020.41.

Inhibition of HIF-1α enhances anti-tumor effects of dendritic cell-based vaccination in a mouse model of breast cancer.

Kheshtchin N, Arab S, Ajami M, Mirzaei R, Ashourpour M, Mousavi N Cancer Immunol Immunother. 2016; 65(10):1159-67.

PMID: 27497816 PMC: 11029746. DOI: 10.1007/s00262-016-1879-5.

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer.

Chouaib S, Noman M, Kosmatopoulos K, Curran M Oncogene. 2016; 36(4):439-445.

PMID: 27345407 PMC: 5937267. DOI: 10.1038/onc.2016.225.

Targeting hypoxia at the forefront of anticancer immune responses.

Noman M, Chouaib S Oncoimmunology. 2015; 3(12):e954463.

PMID: 25964858 PMC: 4353170. DOI: 10.4161/21624011.2014.954463.

Hypoxia promotes tumor growth in linking angiogenesis to immune escape.

Chouaib S, Messai Y, Couve S, Escudier B, Hasmim M, Noman M Front Immunol. 2012; 3:21.

PMID: 22566905 PMC: 3341970. DOI: 10.3389/fimmu.2012.00021.