Middle Cerebral Artery Occlusion Model in Rodents: Methods and Potential Pitfalls

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2011 Feb 19

PMID 21331357

Citations 129

Authors

Fudong Liu

Louise D McCullough

Affiliations

Soon will be listed here.

Abstract

A variety of animal models have been developed for modeling ischemic stroke. The middle cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents. While the MCAO model provides stroke researchers with an excellent platform to investigate the disease, controversial or even paradoxical results are occasionally seen in the literature utilizing this model. Various factors exert important effects on the outcome in this stroke model, including the age and sex of the animal examined. This paper discusses emerging information on the effects of age and sex on ischemic outcomes after MCAO, with an emphasis on mouse models of stroke.

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