Human Immunodeficiency Virus Infection and Hodgkin's Lymphoma in South Africa: An Emerging Problem

Overview

Journal Adv Hematol

Publisher Wiley

Specialty Hematology

Date 2011 Feb 19

PMID 21331149

Citations 11

Authors

Moosa Patel

Vinitha Philip

Fatima Fazel

Affiliations

Soon will be listed here.

Abstract

Hodgkin's lymphoma (HL) occurs with increasing frequency in human-immunodeficiency-virus-(HIV-) infected individuals. The natural history and behaviour of HIV-HL is different, being more atypical and aggressive. The association between HIV and HL appears to be primarily EBV driven. HAART use does not significantly impact on the incidence of HL. Indeed, the risk of HL has increased in the post-HAART era. However, the advent of HAART has brought renewed hope, allowing standard therapeutic options to be used more optimally, with better treatment outcomes. Despite the renewed optimism, the overall survival of HIV-HL patients remains less favourable than that in HIV-seronegative patients. This is particularly true in sub-Saharan Africa, where there is a significant burden of HIV/AIDS and where more than half the patients are HAART naive at diagnosis of HL. The similarities and differences of a South African cohort of HIV-HL are presented in this paper.

Citing Articles

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Feasibility of Cell-Free DNA Collection and Clonal Immunoglobulin Sequencing in South African Patients With HIV-Associated Lymphoma.

Vogt S, Patel M, Lakha A, Philip V, Omar T, Ashmore P JCO Glob Oncol. 2021; 7:611-621.

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References

Takegawa S, Jin Z, Nakayama T, Oyama T, Hieshima K, Nagakubo D . Expression of CCL17 and CCL22 by latent membrane protein 1-positive tumor cells in age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder. Cancer Sci. 2008; 99(2):296-302. PMC: 11158311. DOI: 10.1111/j.1349-7006.2007.00687.x. View

Carbone A, Gloghini A, Larocca L, Antinori A, Falini B, Tirelli U . Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells. Blood. 1999; 93(7):2319-26. View

Sitas F, Bezwoda W, Levin V, Ruff P, Kew M, Hale M . Association between human immunodeficiency virus type 1 infection and cancer in the black population of Johannesburg and Soweto, South Africa. Br J Cancer. 1997; 75(11):1704-7. PMC: 2223539. DOI: 10.1038/bjc.1997.290. View

Garcia-Noblejas A, Nieto S, Liberal R, Cannata J, Steegmann J, Fernandez-Ranada J . Intracerebral Hodgkin's lymphoma in a patient with human immunodeficiency virus. Haematologica. 2007; 92(6):e72-3. DOI: 10.3324/haematol.11291. View

Poppema S, Lai R, Visser L, Yan X . CD45 (leucocyte common antigen) expression in T and B lymphocyte subsets. Leuk Lymphoma. 1996; 20(3-4):217-22. DOI: 10.3109/10428199609051610. View

Stein L, Urban M, OConnell D, Yu X, Beral V, Newton R . The spectrum of human immunodeficiency virus-associated cancers in a South African black population: results from a case-control study, 1995-2004. Int J Cancer. 2008; 122(10):2260-5. DOI: 10.1002/ijc.23391. View

Sitas F, Carrara H, Patel M, Ruff P, Sur R, Jentsch U . The spectrum of HIV-1 related cancers in South Africa. Int J Cancer. 2000; 88(3):489-92. DOI: 10.1002/1097-0215(20001101)88:3<489::aid-ijc25>3.0.co;2-q. View

Spina M, Gabarre J, Rossi G, Fasan M, Schiantarelli C, Nigra E . Stanford V regimen and concomitant HAART in 59 patients with Hodgkin disease and HIV infection. Blood. 2002; 100(6):1984-8. DOI: 10.1182/blood-2002-03-0989. View

Klein U, Dalla-Favera R . Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol. 2007; 8(1):22-33. DOI: 10.1038/nri2217. View

10.

Nakayama T, Hieshima K, Nagakubo D, Sato E, Nakayama M, Kawa K . Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus. J Virol. 2004; 78(4):1665-74. PMC: 369498. DOI: 10.1128/jvi.78.4.1665-1674.2004. View

11.

Rubio R . Hodgkin's disease associated with human immunodeficiency virus infection. A clinical study of 46 cases. Cooperative Study Group of Malignancies Associated with HIV Infection of Madrid. Cancer. 1994; 73(9):2400-7. DOI: 10.1002/1097-0142(19940501)73:9<2400::aid-cncr2820730925>3.0.co;2-c. View

12.

Connors J . Challenging problems: coincident pregnancy, HIV infection, and older age. Hematology Am Soc Hematol Educ Program. 2008; :334-9. DOI: 10.1182/asheducation-2008.1.334. View

13.

Biggar R, Jaffe E, Goedert J, Chaturvedi A, Pfeiffer R, Engels E . Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS. Blood. 2006; 108(12):3786-91. PMC: 1895473. DOI: 10.1182/blood-2006-05-024109. View

14.

Hartmann P, Rehwald U, Salzberger B, Franzen C, Sieber M, Wohrmann A . BEACOPP therapeutic regimen for patients with Hodgkin's disease and HIV infection. Ann Oncol. 2003; 14(10):1562-9. DOI: 10.1093/annonc/mdg408. View

15.

Carbone A, Gloghini A, Serraino D, Spina M . HIV-associated Hodgkin lymphoma. Curr Opin HIV AIDS. 2009; 4(1):3-10. DOI: 10.1097/COH.0b013e32831a722b. View

16.

Spitzer T, Ambinder R, Lee J, Kaplan L, Wachsman W, Straus D . Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant. 2007; 14(1):59-66. PMC: 4524737. DOI: 10.1016/j.bbmt.2007.03.014. View

17.

Hentrich M, Maretta L, Chow K, Bogner J, Schurmann D, Neuhoff P . Highly active antiretroviral therapy (HAART) improves survival in HIV-associated Hodgkin's disease: results of a multicenter study. Ann Oncol. 2006; 17(6):914-9. DOI: 10.1093/annonc/mdl063. View

18.

Tirelli U, Errante D, Dolcetti R, Gloghini A, Serraino D, Vaccher E . Hodgkin's disease and human immunodeficiency virus infection: clinicopathologic and virologic features of 114 patients from the Italian Cooperative Group on AIDS and Tumors. J Clin Oncol. 1995; 13(7):1758-67. DOI: 10.1200/JCO.1995.13.7.1758. View

19.

Xicoy B, Ribera J, Miralles P, Berenguer J, Rubio R, Mahillo B . Results of treatment with doxorubicin, bleomycin, vinblastine and dacarbazine and highly active antiretroviral therapy in advanced stage, human immunodeficiency virus-related Hodgkin's lymphoma. Haematologica. 2007; 92(2):191-8. DOI: 10.3324/haematol.10479. View

20.

Lyter D, Bryant J, Thackeray R, Rinaldo C, Kingsley L . Incidence of human immunodeficiency virus-related and nonrelated malignancies in a large cohort of homosexual men. J Clin Oncol. 1995; 13(10):2540-6. DOI: 10.1200/JCO.1995.13.10.2540. View