New Insights into the Role of TFIIB in Transcription Initiation

Overview

Journal Transcription

Specialty Molecular Biology

Date 2011 Feb 18

PMID 21326885

Citations 9

Authors

Yuming Wang

Stefan Ge Roberts

Affiliations

Soon will be listed here.

Abstract

The general transcription factor TFIIB plays essential, but as yet unclear, roles in transcription initiation by RNA polymerase II. We recently found that phosphorylation of TFIIB is required for productive transcription. We discuss the implications of this work for the functions of TFIIB in promoter escape and gene loop formation.

Citing Articles

Beyond the canonical role of TFIIB in eukaryotic transcription.

OBrien M, Ansari A Curr Genet. 2021; 68(1):61-67.

PMID: 34797379 PMC: 8602988. DOI: 10.1007/s00294-021-01223-x.

RNA polymerase II plays an active role in the formation of gene loops through the Rpb4 subunit.

Allepuz-Fuster P, OBrien M, Gonzalez-Polo N, Pereira B, Dhoondia Z, Ansari A Nucleic Acids Res. 2019; 47(17):8975-8987.

PMID: 31304538 PMC: 6753479. DOI: 10.1093/nar/gkz597.

Linking Core Promoter Classes to Circadian Transcription.

Westermark P PLoS Genet. 2016; 12(8):e1006231.

PMID: 27504829 PMC: 4978467. DOI: 10.1371/journal.pgen.1006231.

Arabidopsis CBP1 Is a Novel Regulator of Transcription Initiation in Central Cell-Mediated Pollen Tube Guidance.

Li H, Zhu S, Zhang M, Wang T, Liang L, Xue Y Plant Cell. 2015; 27(10):2880-93.

PMID: 26462908 PMC: 4682316. DOI: 10.1105/tpc.15.00370.

A role for CF1A 3' end processing complex in promoter-associated transcription.

Al Husini N, Kudla P, Ansari A PLoS Genet. 2013; 9(8):e1003722.

PMID: 23966880 PMC: 3744418. DOI: 10.1371/journal.pgen.1003722.

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