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The Contribution of HIV-discordant Relationships to New HIV Infections in Rakai, Uganda

Overview
Journal AIDS
Specialty Infectious Diseases
Date 2011 Feb 18
PMID 21326076
Citations 28
Authors
Ron Gray
Victor Ssempiija
James Shelton
David Serwadda
Fred Nalugoda
Joseph Kagaayi
Godfrey Kigozi
Maria J Wawer
Affiliations
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Abstract

We determined HIV infections in the Rakai cohort before (82/9434) and after (131/13082) the availability of antiretroviral therapy (ART). The proportions of total HIV infections pre-ART and post-ART were 18.3% and 13.7%, respectively, among identifiable HIV-discordant couples, 23.2% and 26.0%, respectively, in concordant HIV-negative couples, 29.3% and 17.6% in married persons with unknown partner status, and 29.3% and 42.7% in the unmarried. Voluntary counseling and testing targeting discordant couples is unlikely to have a substantial impact in this setting.

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References
1.
Dunkle K, Stephenson R, Karita E, Chomba E, Kayitenkore K, Vwalika C . New heterosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda: an analysis of survey and clinical data. Lancet. 2008; 371(9631):2183-91. DOI: 10.1016/S0140-6736(08)60953-8. View
2.
J Wawer M, H Gray R, Sewankambo N, Serwadda D, Li X, Laeyendecker O . Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005; 191(9):1403-9. DOI: 10.1086/429411. View
3.
Donnell D, Baeten J, Kiarie J, Thomas K, Stevens W, Cohen C . Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet. 2010; 375(9731):2092-8. PMC: 2922041. DOI: 10.1016/S0140-6736(10)60705-2. View
4.
Marston M, Slaymaker E, Cremin I, Floyd S, McGrath N, Kasamba I . Trends in marriage and time spent single in sub-Saharan Africa: a comparative analysis of six population-based cohort studies and nine Demographic and Health Surveys. Sex Transm Infect. 2009; 85 Suppl 1:i64-71. PMC: 2654103. DOI: 10.1136/sti.2008.034249. View
5.
Wawer M, Gray R, Sewankambo N, Serwadda D, Paxton L, Berkley S . A randomized, community trial of intensive sexually transmitted disease control for AIDS prevention, Rakai, Uganda. AIDS. 1998; 12(10):1211-25. DOI: 10.1097/00002030-199810000-00014. View