Transgenic Overexpression of P23 Induces Spontaneous Hydronephrosis in Mice

Overview

Journal Int J Exp Pathol

Publisher Wiley

Specialty Pathology

Date 2011 Feb 18

PMID 21323770

Citations 5

Authors

Jaehoon Lee

Hye Jin Kim

Jung Ah Moon

Young Hoon Sung

In-Jeoung Baek

Jae-Il Roh

Na Young Ha

Seung-Yeon Kim

Young Yil Bahk

Jong Eun Lee

Tae Hyun Yoo

Han-Woong Lee

Affiliations

Soon will be listed here.

Abstract

p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed kidney abnormalities closely resembling human hydronephrosis. Consistently, kidney functions deteriorate significantly in the p23 TG mice compared to their wild-type (WT) littermates. Furthermore, the expression of target genes for aryl hydrocarbon receptor (AhR), such as cytochrome P450, family 1, subfamily A, polypeptide 1 (Cyp1A1) and cytochrome P450, family 1, subfamily B, polypeptide 1 (Cyp1B1), were induced in the kidneys of the p23 TG mice. These results indicate that the overexpression of p23 contributes to the development of hydronephrosis through the upregulation of the AhR pathway in vivo.

Citing Articles

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