Umbilical Cord Blood Procalcitonin Level in Early Neonatal Infections: a 4-year University Hospital Cohort Study

Overview

Journal Eur J Clin Microbiol Infect Dis

Publisher Springer

Specialties Infectious Diseases
Microbiology

Date 2011 Feb 12

PMID 21311939

Citations 12

Authors

N Joram

J-B Muller

S Denizot

J-L Orsonneau

J Caillon

J-C Roze

C Gras-le Guen

Affiliations

Soon will be listed here.

Abstract

This article describes a study of procalcitonin (PCT) measured in cord blood as a discriminating marker of early-onset neonatal infection. This was a monocenter retrospective study with prospective collection of data including all babies born during the study period. Those presenting infection risk factors had PCT measurement. Three groups were defined: certainly infected, probably infected, and non-infected. A total of 12,485 newborns were included, 2151 had PCT measurement, and 26 were infected. Receiver operating curves of PCT determined 0.6 ng/ml as the best cut-off, with an area under the curve of 0.96 (CI 95% 0.95-0.98). Sensitivity, specificity, positive and negative predictive value and positive and negative likelihood ratios were 0.92 (range, 0.75-0.98), 0.97 (0.96-0.98), 0.28 (0.20-0.36), 0.99 (0.99-0.99), 32 (24-41) and 0.08 (0.02-0.3), respectively. Post-test probabilities were 28% (23-33) if the test was positive, and less than 0.001% (0-1.10(-5)) if the test was negative. Gestational age between 28 and 32 weeks (OR 4.4; range, 1.2-16.2) and pH at birth < 7.10 (OR 2.9; 1.1-7.4) were other independent factors of increasing PCT (p < 0.05). PCT measured in umbilical cord blood is reliable to detect early infected and non-infected newborns.

Citing Articles

The diagnostic accuracy of umbilical cord procalcitonin in predicting early-onset neonatal infection.

Nguyen T, Thi D, Truong Q, Pham T PLoS One. 2025; 20(1):e0316987.

PMID: 39821188 PMC: 11737792. DOI: 10.1371/journal.pone.0316987.

Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection.

Tran L, Giang T, Nguyen T Cureus. 2024; 16(5):e59887.

PMID: 38721478 PMC: 11078120. DOI: 10.7759/cureus.59887.

Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis.

Yadav P, Agarwal K, Rani A, Dewan R, Chellani H Eur J Obstet Gynecol Reprod Biol X. 2023; 19:100221.

PMID: 37593584 PMC: 10430163. DOI: 10.1016/j.eurox.2023.100221.

Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa.

Ezinmegnon S, Mommert M, Bartolo F, Agbota G, Darius S, Briand V Sci Rep. 2022; 12(1):21458.

PMID: 36509812 PMC: 9743113. DOI: 10.1038/s41598-022-25892-x.

Umbilical Cord Procalcitonin to Detect Early-Onset Sepsis in Newborns: A Promising Biomarker.

Dongen O, van Leeuwen L, de Groot P, Vollebregt K, Schiering I, Wevers B Front Pediatr. 2021; 9:779663.

PMID: 34956986 PMC: 8704118. DOI: 10.3389/fped.2021.779663.

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