The Genetics of Teratocarcinoma Transplantation: Tumor Formation in Allogeneic Hosts by the Embryonal Carcinoma Cell Lines F9 and PCC3

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 2011 Feb 9

PMID 21302063

Citations 14

Authors

P R Avner

W F Dove

P Dubois

J A Gaillard

J L Guenet

F Jacob

H Jakob

A Shedlovsky

Affiliations

Soon will be listed here.

Abstract

Two cultured lines of murine embryonal carcinoma, F9 and PCC3, have been grafted to a variety of allogeneic hosts. The host strains have been classified by their resistance or sensitivity to these carcinomas. Resistance seems to be immunological in nature.Allograft rejection does not correlate withH-2 haplotype, and seems to be controlled by a limited number of recessive factors, presumably histocompatibility genes. We infer that these factors have limited polymorphism in the mouse species. Recombinational analysis of strain A/He has revealed the presence of a recessive factor linked to theH-2 locus. Tumor resistance of strains C57BL/6 and AKR appears to result from the interaction of dominant or semi-dominant factors in theH-2 region with other recessive elements in the genetic background.Though F(1) hybrids between resistant mouse strains and the syngeneic strain 129 are largely tumor-sensitive, a low level of hybrid resistance to F9 has been observed and shown to be eliminated by X-irradiation.

Citing Articles

Susceptibility of allogeneic mice to teratocarcinoma 402AX.

Ostrand-Rosenberg S, Rider T, Twarowski A Immunogenetics. 2012; 10(6):607-12.

PMID: 22457940 DOI: 10.1007/BF01572595.

Semisyngeneic hybrid resistance to murine teratocarcinoma cells.

Bishop G, Dove W Immunogenetics. 2012; 10(4):383-93.

PMID: 22457930 DOI: 10.1007/BF01561588.

Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, flank H-2.

Shedlovsky A, Clipson L, Vandeberg J, Dove W Immunogenetics. 1981; 13(5):413-9.

PMID: 7298086 DOI: 10.1007/BF00346022.

Teratocarcinoma transplantation rejection loci: genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles.

Levine A, Teresky A Immunogenetics. 1981; 13(5):405-12.

PMID: 7298085 DOI: 10.1007/BF00346021.

Minor histocompatibility antigen expression on F9 embryonal carcinoma cells revealed by T-cell mediated responses.

Simmler M, Avner P, LEVY J Immunogenetics. 1982; 16(4):349-54.

PMID: 6983494 DOI: 10.1007/BF00372306.

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