Photo-crosslinked and PH Sensitive Polymersomes for Triggering the Loading and Release of Cargo

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2011 Feb 9

PMID 21301743

Citations 9

Authors

Jens Gaitzsch

Dietmar Appelhans

David Grafe

Petra Schwille

Brigitte Voit

Affiliations

Soon will be listed here.

Abstract

Crosslinkable and pH-sensitive amphiphilic block copolymers are promising candidates to establish pH-stable and permeable vesicles for synthetic biology. Here, we report the fabrication of crosslinked and pH-stable polymersomes as swellable vesicles for the pH-dependent loading and release of small dye molecules.

Citing Articles

Boosting Microfluidic Enzymatic Cascade Reactions with pH-Responsive Polymersomes by Spatio-Chemical Activity Control.

Koball A, Obst F, Gaitzsch J, Voit B, Appelhans D Small Methods. 2024; 8(12):e2400282.

PMID: 38989686 PMC: 11671858. DOI: 10.1002/smtd.202400282.

Photo-Cross-Linking Polymersome Nanoreactors with Size-Selective Permeability.

Rijpkema S, van Egeraat R, Li W, Wilson D Macromolecules. 2022; 55(13):5744-5755.

PMID: 35847241 PMC: 9281476. DOI: 10.1021/acs.macromol.2c00248.

Artificial Organelles with Orthogonal-Responsive Membranes for Protocell Systems: Probing the Intrinsic and Sequential Docking and Diffusion of Cargo into Two Coexisting Avidin-Polymersomes.

Wang X, Moreno S, Boye S, Wang P, Liu X, Lederer A Adv Sci (Weinh). 2021; 8(11):e2004263.

PMID: 34105298 PMC: 8188225. DOI: 10.1002/advs.202004263.

Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis.

Kocere A, Resseguier J, Wohlmann J, Skjeldal F, Khan S, Speth M EBioMedicine. 2020; 58:102902.

PMID: 32707448 PMC: 7381511. DOI: 10.1016/j.ebiom.2020.102902.

Stimulus-responsive vesicular polymer nano-integrators for drug and gene delivery.

Mu X, Gan S, Wang Y, Li H, Zhou G Int J Nanomedicine. 2019; 14:5415-5434.

PMID: 31409996 PMC: 6645615. DOI: 10.2147/IJN.S203555.