19S and 7-8S Forms of IgM Antibody to Hepatitis B Core Antigen in Acute Icteric Hepatitis Superimposed on Hepatitis B Surface Antigen Carriage

Overview

Journal Infection

Date 1990 Nov 1

PMID 2127587

Citations 1

Authors

N C Tassopoulos

M H Sjogren

R H Purcell

Affiliations

Soon will be listed here.

Abstract

The 19S and 7-8S forms of IgM antibody to hepatitis B core antigen (IgM anti-HBc) were separated by rate-zonal centrifugation from the serum of 20 Greek hepatitis B surface antigen (HBsAg) carriers with a superimposed acute icteric hepatitis positive for IgM anti-HBc by a radioimmunoassay. Serological markers of hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis D virus (HDV) infections were detected with radioimmunoassays and serum HBV DNA was detected with molecular hybridization techniques. Eighteen of the 20 carriers showed a predominance of one or the other form of IgM anti-HBc. Low molecular weight (7-8S) IgM anti-HBc was observed more frequently in HDV superinfection (5/9) and was related to a low mortality (1/9). In contrast, 19S IgM anti-HBc was observed more frequently in reactivation of chronic hepatitis B (6/9) and was related to a high mortality (5/9). These preliminary data show that in HBsAg carriers with a superimposed acute icteric hepatitis, predominance of 19S IgM anti-HBc is frequently associated with a severe clinical course; the opposite is true for predominance of 7-8S IgM anti-HBc.

Citing Articles

Acute hepatitis B virus infection or acute exacerbation of chronic hepatitis B infection: the differential serological diagnosis.

Ponde R Eur J Clin Microbiol Infect Dis. 2015; 35(1):29-40.

PMID: 26581426 DOI: 10.1007/s10096-015-2522-7.

References

Smedile A, Lavarini C, Crivelli O, Raimondo G, Fassone M, Rizzetto M . Radioimmunoassay detection of IgM antibodies to the HBV-associated delta (delta) antigen:" clinical significance in delta infection. J Med Virol. 1982; 9(2):131-8. DOI: 10.1002/jmv.1890090208. View

Theofilopoulos A, Burtonboy G, LoSpalluto J, ZIFF M . IgM rheumatoid factor and low molecular weight IgM. An association with vasculitis. Arthritis Rheum. 1974; 17(3):272-84. DOI: 10.1002/art.1780170312. View

Tsuda F, Naito S, Takai E, Akahane Y, Furuta S, Miyakawa Y . Low molecular weight (7s) immunoglobulin M antibody against hepatitis B core antigen in the serum for differentiating acute from persistent hepatitis B virus infection. Gastroenterology. 1984; 87(1):159-64. View

Sjogren M, Hoofnagle J . Immunoglobulin M antibody to hepatitis B core antigen in patients with chronic type B hepatitis. Gastroenterology. 1985; 89(2):252-8. DOI: 10.1016/0016-5085(85)90323-3. View

Tassopoulos N, PAPAEVANGELOU G, Ticehurst J, Feinstone S, Purcell R . Search for hepatitis B virus DNA in sera from patients with acute type B or non-A, non-B hepatitis. J Hepatol. 1986; 2(3):410-8. DOI: 10.1016/s0168-8278(86)80052-6. View

Stobo J, Tomasi T . A Low Molecular Weight Immunoglobulin Antigenically Related to 19 S IgM. J Clin Invest. 1967; 46(8):1329-37. PMC: 297134. DOI: 10.1172/JCI105625. View

Tassopoulos N, PAPAEVANGELOU G, Sjogren M, Gerin J, Purcell R . Natural history of acute hepatitis B surface antigen-positive hepatitis in Greek adults. Gastroenterology. 1987; 92(6):1844-50. DOI: 10.1016/0016-5085(87)90614-7. View

Rothfield N, Frangione B, FRANKLIN E . SLOWLY SEDIMENTING MERCAPTOETHANOL-RESISTANT ANTINUCLEAR FACTORS RELATED ANTIGENICALLY TO M IMMUNOGLOBULINS (GAMMA-1M-GLOBULIN) IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. J Clin Invest. 1965; 44:62-72. PMC: 442019. DOI: 10.1172/JCI105127. View

Papaevangelou G, Tassopoulos N, Stathopoulou P . Diagnostic value of anti-HBc IgM in high HBV prevalence areas. J Med Virol. 1984; 13(4):393-9. DOI: 10.1002/jmv.1890130411. View

10.

Gerlich W, Uy A, Lambrecht F, THOMSSEN R . Cutoff levels of immunoglobulin M antibody against viral core antigen for differentiation of acute, chronic, and past hepatitis B virus infections. J Clin Microbiol. 1986; 24(2):288-93. PMC: 268891. DOI: 10.1128/jcm.24.2.288-293.1986. View

11.

Kuo G, Choo Q, Alter H, Gitnick G, Redeker A, Purcell R . An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989; 244(4902):362-4. DOI: 10.1126/science.2496467. View

12.

Metzger H . Structure and function of gamma M macroglobulins. Adv Immunol. 1970; 12:57-116. DOI: 10.1016/s0065-2776(08)60168-6. View

13.

Sjogren M, Bancroft W, Hoofnagle J, Sosebee J, Lemon S . Clinical significance of low molecular weight (7-8S) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections. Gastroenterology. 1986; 91(1):168-73. DOI: 10.1016/0016-5085(86)90454-3. View

14.

TREY C . The fulminant hepatic failure surveillance study. Brief review of the effects of presumed etiology and age of survival. Can Med Assoc J. 1972; 106:525-8. PMC: 1945148. View

15.

Sjogren M, Lemon S . Low-molecular-weight IgM antibody to hepatitis B core antigen in chronic infections with hepatitis B virus. J Infect Dis. 1983; 148(3):445-51. DOI: 10.1093/infdis/148.3.445. View

16.

Berninger M, Hammer M, Hoyer B, Gerin J . An assay for the detection of the DNA genome of hepatitis B virus in serum. J Med Virol. 1982; 9(1):57-68. DOI: 10.1002/jmv.1890090109. View

17.

Hoofnagle J, Ponzetto A, Mathiesen L, WAGGONER J, Bales Z, Seeff L . Serological diagnosis of acute viral hepatitis. Dig Dis Sci. 1985; 30(11):1022-7. DOI: 10.1007/BF01315598. View

18.

McDougal J, Harisdangkul V, Christian C . Naturally-ocurring low molecular weight IgM in patients with rheumatoid arthritis, systemic lupus erythematosus, and macroglobulinemia. II. Structural studies and comparison of some physicochemical properties of reduced and alkylated IgM, and low.... J Immunol. 1975; 115(1):223-9. View

19.

Rizzetto M, Shih J, Gerin J . The hepatitis B virus-associated delta antigen: isolation from liver, development of solid-phase radioimmunoassays for delta antigen and anti-delta and partial characterization of delta antigen. J Immunol. 1980; 125(1):318-24. View

20.

Lemon S, Gates N, Simms T, Bancroft W . IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus. J Infect Dis. 1981; 143(6):803-9. DOI: 10.1093/infdis/143.6.803. View