Neurogenesis in Adult Human Brain After Traumatic Brain Injury

Overview

Journal J Neurotrauma

Publisher Mary Ann Liebert

Specialties Emergency Medicine
Neurology

Date 2011 Feb 1

PMID 21275797

Citations 73

Authors

Weiming Zheng

Qichuan Zhuge

Ming Zhong

Gourong Chen

Bei Shao

Hong Wang

XiaoOu Mao

Lin Xie

Kunlin Jin

Affiliations

Soon will be listed here.

Abstract

While much work has been conducted regarding the neurogenesis response to traumatic brain injury (TBI) in rodents, it remains largely unknown whether neurogenesis in adult human brain also responds to TBI in a similar manner. Here, we performed immunocytochemistry on 11 brain specimens from patients with traumatic brain injury, who underwent surgical intervention. We found that expression of neural stem/progenitor cell (NSC) protein markers, including DCX, TUC4, PSA-NCAM, SOX2 and NeuroD, was increased in the perilesional cortex of human brain after TBI compared to that of normal brain. Confocal images showed that these NSC proteins were expressed in one single cell. We also found that proliferative markers were expressed in NSC protein-positive cells after TBI, and the number of proliferative NSCs was significantly increased after TBI. Our data suggest that TBI may also induce neurogenesis in human brain.

Citing Articles

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Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury.

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References

Fanarraga , AVILA , Zabala . Expression of unphosphorylated class III beta-tubulin isotype in neuroepithelial cells demonstrates neuroblast commitment and differentiation. Eur J Neurosci. 1999; 11(2):516-527. View

Sgubin D, Aztiria E, Perin A, Longatti P, Leanza G . Activation of endogenous neural stem cells in the adult human brain following subarachnoid hemorrhage. J Neurosci Res. 2007; 85(8):1647-55. DOI: 10.1002/jnr.21303. View

Thau-Zuchman O, Shohami E, Alexandrovich A, Leker R . Vascular endothelial growth factor increases neurogenesis after traumatic brain injury. J Cereb Blood Flow Metab. 2010; 30(5):1008-16. PMC: 2949187. DOI: 10.1038/jcbfm.2009.271. View

Chirumamilla S, Sun D, Bullock M, Colello R . Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system. J Neurotrauma. 2002; 19(6):693-703. DOI: 10.1089/08977150260139084. View

Tatsumi K, Haga S, Matsuyoshi H, Inoue M, Manabe T, Makinodan M . Characterization of cells with proliferative activity after a brain injury. Neurochem Int. 2005; 46(5):381-9. DOI: 10.1016/j.neuint.2004.12.007. View

Zhang C, Zou Y, He W, Gage F, Evans R . A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008; 451(7181):1004-7. DOI: 10.1038/nature06562. View

Sundholm-Peters N, Yang H, Goings G, Walker A, Szele F . Subventricular zone neuroblasts emigrate toward cortical lesions. J Neuropathol Exp Neurol. 2005; 64(12):1089-100. DOI: 10.1097/01.jnen.0000190066.13312.8f. View

Saxe M, Battaglia F, Wang J, Malleret G, David D, Monckton J . Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A. 2006; 103(46):17501-6. PMC: 1859958. DOI: 10.1073/pnas.0607207103. View

Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N . Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci. 2005; 21(1):1-14. DOI: 10.1111/j.1460-9568.2004.03813.x. View

10.

Jin K, Galvan V, Xie L, Mao X, Gorostiza O, Bredesen D . Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice. Proc Natl Acad Sci U S A. 2004; 101(36):13363-7. PMC: 516572. DOI: 10.1073/pnas.0403678101. View

11.

Shors T, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E . Neurogenesis in the adult is involved in the formation of trace memories. Nature. 2001; 410(6826):372-6. DOI: 10.1038/35066584. View

12.

Mullen R, Buck C, Smith A . NeuN, a neuronal specific nuclear protein in vertebrates. Development. 1992; 116(1):201-11. DOI: 10.1242/dev.116.1.201. View

13.

Komitova M, Eriksson P . Sox-2 is expressed by neural progenitors and astroglia in the adult rat brain. Neurosci Lett. 2004; 369(1):24-7. DOI: 10.1016/j.neulet.2004.07.035. View

14.

Ewing-Cobbs L, Barnes M, Fletcher J . Early brain injury in children: development and reorganization of cognitive function. Dev Neuropsychol. 2003; 24(2-3):669-704. DOI: 10.1080/87565641.2003.9651915. View

15.

Chiaretti A, Antonelli A, Genovese O, Pezzotti P, Di Rocco C, Viola L . Nerve growth factor and doublecortin expression correlates with improved outcome in children with severe traumatic brain injury. J Trauma. 2008; 65(1):80-5. DOI: 10.1097/TA.0b013e31805f7036. View

16.

Yoshimura S, Takagi Y, Harada J, Teramoto T, Thomas S, Waeber C . FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc Natl Acad Sci U S A. 2001; 98(10):5874-9. PMC: 33306. DOI: 10.1073/pnas.101034998. View

17.

Urrea C, Castellanos D, Sagen J, Tsoulfas P, Bramlett H, Dietrich W . Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat. Restor Neurol Neurosci. 2007; 25(1):65-76. View

18.

Jin K, Peel A, Mao X, Xie L, Cottrell B, Henshall D . Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci U S A. 2003; 101(1):343-7. PMC: 314187. DOI: 10.1073/pnas.2634794100. View

19.

Jin K, Sun Y, Xie L, Peel A, Mao X, Batteur S . Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol Cell Neurosci. 2003; 24(1):171-89. DOI: 10.1016/s1044-7431(03)00159-3. View

20.

Song H, Stevens C, Gage F . Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci. 2002; 5(5):438-45. DOI: 10.1038/nn844. View