Limited Diagnostic and Predictive Values of Dual-time-point 18F FDG PET/CT for Differentiation of Incidentally Detected Thyroid Nodules

Overview

Journal Ann Nucl Med

Date 2011 Jan 29

PMID 21271313

Citations 10

Authors

Seong-Jang Kim

Bo Hyun Kim

Yun Kyung Jeon

Sang Soo Kim

In Joo Kim

Affiliations

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Abstract

Objective: To assess usefulness of dual-time-point (18)F FDG PET/CT to differentiate malignant from benign thyroid nodules and predict the potential factor for malignancy.

Methods: Fifty patients (age 38-83 years, mean 58 ± 10.6 years) with thyroid nodule were recruited. The (18)F FDG PET/CT images were analyzed visually and quantitatively.

Results: The optimal visual grade of early and delayed images was >grade 3. When SUV(max1) of >2.9 was used as cut off point, the sensitivity and specificity were 55.5 and 63.4%. When SUV(max2) was >3.1, the sensitivity and specificity were 88.8 and 43.9%. When %ΔSUV(max) was ≤9.09%, the sensitivity and specificity were 33.3 and 87.8%. ROC analyses showed that all indices had similar efficacy without significances. No definite predictor could be found for malignant nodules.

Conclusion: The dual-time-point (18)F FDG PET/CT is not a useful method for differentiating malignant and benign nodules.

Citing Articles

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de Leijer J, Metman M, van der Hoorn A, Brouwers A, Kruijff S, van Hemel B Front Endocrinol (Lausanne). 2021; 12:723394.

PMID: 34744999 PMC: 8564374. DOI: 10.3389/fendo.2021.723394.

Correlation of whole-bone marrow dual-time-point F-FDG, as measured by a CT-based method of PET/CT quantification, with response to treatment in newly diagnosed multiple myeloma patients.

Zirakchian Zadeh M, Raynor W, Ostergaard B, Hess S, Yellanki D, Ayubcha C Am J Nucl Med Mol Imaging. 2020; 10(5):257-264.

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The role of dual time point PET/CT for distinguishing malignant from benign focal 18F-FDG uptake duodenal lesions.

Sa R, Zhao H, Dai Y, Guan F Medicine (Baltimore). 2018; 97(38):e12521.

PMID: 30235771 PMC: 6160135. DOI: 10.1097/MD.0000000000012521.

Dual time-point F-FDG PET/CT imaging with multiple metabolic parameters in the differential diagnosis of malignancy-suspected bone/joint lesions.

Shen C, Qiu Z, Sun Z, Wei W, Song H, Zhang X Oncotarget. 2017; 8(41):71188-71196.

PMID: 29050355 PMC: 5642630. DOI: 10.18632/oncotarget.17140.

A prospective cohort study to assess the role of FDG-PET in differentiating benign and malignant follicular neoplasms.

Pathak K, Goertzen A, Nason R, Klonisch T, Leslie W Ann Med Surg (Lond). 2016; 12:27-31.

PMID: 27872746 PMC: 5109254. DOI: 10.1016/j.amsu.2016.10.008.