Classical and Alternative Components of the Mitochondrial Respiratory Chain in Pathogenic Fungi As Potential Therapeutic Targets

Overview

Journal J Bioenerg Biomembr

Publisher Springer

Specialties Biochemistry
Biology
Endocrinology

Date 2011 Jan 29

PMID 21271279

Citations 19

Authors

Vicente de Paulo Martins

Taisa Magnani Dinamarco

Carlos Curti

Sergio Akira Uyemura

Affiliations

Soon will be listed here.

Abstract

The frequency of opportunistic fungal infection has increased drastically, mainly in patients who are immunocompromised due to organ transplant, leukemia or HIV infection. In spite of this, only a few classes of drugs with a limited array of targets, are available for antifungal therapy. Therefore, more specific and less toxic drugs with new molecular targets is desirable for the treatment of fungal infections. In this context, searching for differences between mitochondrial mammalian hosts and fungi in the classical and alternative components of the mitochondrial respiratory chain may provide new potential therapeutic targets for this purpose.

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