Sentinel Lymph Node Detection by an Optical Method Using Scattered Photons

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2011 Jan 25

PMID 21258517

Citations 4

Authors

Franklin Tellier

Rasata Ravelo

Herve Simon

Renee Chabrier

Jerome Steibel

Patrick Poulet

Affiliations

Soon will be listed here.

Abstract

We present a new near infrared optical probe for the sentinel lymph node detection, based on the recording of scattered photons. A two wavelengths setup was developed to improve the detection threshold of an injected dye: the Patent Blue V dye. The method used consists in modulating each laser diode at a given frequency. A Fast Fourier Transform of the recorded signal separates both components. The signal amplitudes are used to compute relative Patent Blue V concentration. Results on the probe using phantoms model and small animal experimentation exhibit a sensitivity threshold of 3.2 µmol/L, which is thirty fold better than the eye visible threshold.

Citing Articles

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A new optical probe for the detection of the sentinel lymph node using patent blue V dye in breast cancer: A preliminary study.

Tellier F, Poulet P, Ghnassia J, Wilt M, Weitbruch D, Rodier J Mol Clin Oncol. 2014; 1(1):143-147.

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Sentinel lymph nodes fluorescence detection and imaging using Patent Blue V bound to human serum albumin.

Tellier F, Steibel J, Chabrier R, Ble F, Tubaldo H, Rasata R Biomed Opt Express. 2012; 3(9):2306-16.

PMID: 23024922 PMC: 3447570. DOI: 10.1364/BOE.3.002306.

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