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Embryonic Stem Cells: Are Useful in Clinic Treatments?

Overview
Journal J Physiol Biochem
Specialties Biochemistry
Physiology
Date 2011 Jan 20
PMID 21246421
Citations 8
Authors
Justo Aznar
Jose Luis Sanchez
Affiliations
Soon will be listed here.
Abstract

It is not uncommon to find statements in the social media and even in some scientific journals declaring that embryonic stem cells can be used in human medicine for therapeutic purposes. In our opinion, this statement does not fit the medical reality. To go into this subject in depth, and if possible to clarify it, we reviewed the most recent literature on clinical trials conducted with embryonic stem cells, concluding that up to the present time, there is only one ongoing clinical trial being carried out with these types of cells to treat a small group of patients with spinal cord injury. The results of this trial have still not been published. In conclusion, at present, there is only evidence of one phase I clinical trial conducted with embryonic stem cells, in comparison to the numerous trials conducted with adult stem cells.

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References
1.
Amariglio N, Hirshberg A, Scheithauer B, Cohen Y, Loewenthal R, Trakhtenbrot L . Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med. 2009; 6(2):e1000029. PMC: 2642879. DOI: 10.1371/journal.pmed.1000029. View
2.
Prentice D, Tarne G . Treating diseases with adult stem cells. Science. 2007; 315(5810):328. DOI: 10.1126/science.315.5810.328b. View
3.
Klimanskaya I, Rosenthal N, Lanza R . Derive and conquer: sourcing and differentiating stem cells for therapeutic applications. Nat Rev Drug Discov. 2007; 7(2):131-42. DOI: 10.1038/nrd2403. View
4.
Tabar V, Tomishima M, Panagiotakos G, Wakayama S, Menon J, Chan B . Therapeutic cloning in individual parkinsonian mice. Nat Med. 2008; 14(4):379-81. PMC: 2786166. DOI: 10.1038/nm1732. View
5.
Chidgey A, Layton D, Trounson A, Boyd R . Tolerance strategies for stem-cell-based therapies. Nature. 2008; 453(7193):330-7. DOI: 10.1038/nature07041. View