The Genomic Landscapes of Inflammation

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2011 Jan 20

PMID 21245163

Citations 84

Authors

Gioacchino Natoli

Serena Ghisletti

Iros Barozzi

Affiliations

Soon will be listed here.

Abstract

Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.

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