Does Minor Histocompatibility Antigen HA-1 Disparity Affect the Occurrence of Graft-versus-host Disease in Tunisian Recipients of Hematopoietic Stem Cells?

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2011 Jan 19

PMID 21243279

Citations 2

Authors

Mohamed Hichem Sellami

Lamia Torjemane

Alejandro Espadas de Arias

Houda Kaabi

Saloua Ladeb

Francesca Poli

Tarek Ben Othmane

Slama Hmida

Affiliations

Soon will be listed here.

Abstract

Introduction: Minor histocompatibility antigen HA-1 (MiHAg-HA-1) disparity between a patient and his or her human leukocyte antigen (HLA) genoidentical donor has been widely associated with an increased risk of graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.

Objective: To examine the effect of HA-1 disparity on the incidence of both acute and chronic graft-versus-host disease in Tunisian recipients of hematopoietic stem cells.

Methods: A total of 60 patients and their 60 respective sibling hematopoietic stem cell donors were enrolled in this study. All patients prophylactically received cyclosporine A and/or methotrexate for graft-versus-host disease. An HA-1 genotyping assay was performed with the SSP-PCR method, and HLA-A*0201- and/or HLA-A*0206-positive samples were identified using the Luminex HLA typing method.

Results: The Luminex HLA typing assay showed that 54 patients were positive for either the HLA-A*0201 or HLA-A*0206 alleles. Among these cases, six pairs were mismatched for MiHAg-HA-1. Both acute and chronic graft-versus-host disease occurred in four mismatched patients (Fisher's p-values were 0.044 and 0.170, respectively). A univariate logistic regression model analysis showed that only acute graft-versus-host disease may be affected by recipient MiHAg-HA-1 disparity (p: 0.041, OR: 6.727), while chronic graft-versus-host disease correlates with both age and recipient/donor sex mismatch (p: 0.014, OR: 8.556 and p: 0.033, OR: 8.664, respectively).

Conclusion: Our findings support previously reported data suggesting a significant association between HA-1 disparity and the risk of acute graft-versus-host disease following hematopoietic stem cell transplantation.

Citing Articles

Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors.

Dzierzak-Mietla M, Markiewicz M, Siekiera U, Mizia S, Koclega A, Zielinska P Bone Marrow Res. 2012; 2012:257086.

PMID: 23193478 PMC: 3502767. DOI: 10.1155/2012/257086.

Pediatrics in Clinics: highlights.

Silva M Clinics (Sao Paulo). 2012; 67(8):859-64.

PMID: 22948450 PMC: 3416888. DOI: 10.6061/clinics/2012(08)01.

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