Are Polycomb Group Bodies Gene Silencing Factories?

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2011 Jan 19

PMID 21241887

Citations 5

Authors

Jacob W Hodgson

Hugh W Brock

Affiliations

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Abstract

Polycomb group (PcG) proteins mediate long-range associations between Hox genes, which correlate with gene repression in vivo. Bantignies et al. (2011) identify a physiological role for the nuclear localization of Hox genes in PcG-mediated gene silencing, strengthening the evidence that nuclear positioning regulates gene expression.

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