Role of Endothelial Nitric Oxide in Cerebrovascular Regulation

Overview

Journal Curr Pharm Biotechnol

Publisher Bentham Science Publishers

Specialties Biotechnology
Pharmacology

Date 2011 Jan 18

PMID 21235451

Citations 24

Authors

Dmitriy N Atochin

Paul L Huang

Affiliations

Soon will be listed here.

Abstract

Endothelial nitric oxide (NO) plays important roles in the vascular system. Animal models that show vascular dysfunction demonstrate the protective role of endothelial NO dependent pathways. This review focuses on the role of endothelial NO in the regulation of cerebral blood flow and vascular tone. We will discuss the importance of NO in cerebrovascular function using animal models with altered endothelial NO production under normal, ischemic and reperfusion conditions, as well as in hyperoxia. Pharmacological and genetic manipulations of the endothelial NO system demonstrate the essential roles of endothelial NO synthase in maintenance of vascular tone and cerebral perfusion under normal and pathological conditions.

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References

Huang P . Unraveling the links between diabetes, obesity, and cardiovascular disease. Circ Res. 2005; 96(11):1129-31. PMC: 3733534. DOI: 10.1161/01.RES.0000170705.56583.45. View

Meng W, Ma J, Ayata C, Hara H, Huang P, Fishman M . ACh dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. Am J Physiol. 1996; 271(3 Pt 2):H1145-50. DOI: 10.1152/ajpheart.1996.271.3.H1145. View

Bhardwaj A, Northington F, Carhuapoma J, Falck J, Harder D, Traystman R . P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate. Am J Physiol Heart Circ Physiol. 2000; 279(4):H1616-24. DOI: 10.1152/ajpheart.2000.279.4.H1616. View

Fabian R, Perez-Polo J, Kent T . Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. Am J Physiol Heart Circ Physiol. 2008; 295(4):H1809-14. PMC: 2593505. DOI: 10.1152/ajpheart.00301.2007. View

Kamii H, Kato I, Kinouchi H, Chan P, Epstein C, AKABANE A . Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase. Stroke. 1999; 30(4):867-71; discussion 872. DOI: 10.1161/01.str.30.4.867. View

Toyoda K, Fujii K, Ibayashi S, Nagao T, Kitazono T, Fujishima M . Role of nitric oxide in regulation of brain stem circulation during hypotension. J Cereb Blood Flow Metab. 1997; 17(10):1089-96. DOI: 10.1097/00004647-199710000-00011. View

Liao J, Zulueta J, Yu F, Peng H, Cote C, Hassoun P . Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest. 1995; 96(6):2661-6. PMC: 185972. DOI: 10.1172/JCI118332. View

Kashiwagi S, Kajimura M, Yoshimura Y, Suematsu M . Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. Circ Res. 2002; 91(12):e55-64. DOI: 10.1161/01.res.0000047529.26278.4d. View

Wei E, KONTOS H, Christman C, DeWitt D, Povlishock J . Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension. Circ Res. 1985; 57(5):781-7. DOI: 10.1161/01.res.57.5.781. View

10.

Sun H, Mayhan W . Temporal effect of alcohol consumption on reactivity of pial arterioles: role of oxygen radicals. Am J Physiol Heart Circ Physiol. 2001; 280(3):H992-H1001. DOI: 10.1152/ajpheart.2001.280.3.H992. View

11.

Kano T, Huang P, Moskowitz M, Lo E . Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo. Neuroscience. 1998; 86(3):695-9. DOI: 10.1016/s0306-4522(98)00179-1. View

12.

Ayata C, Ma J, Meng W, Huang P, Moskowitz M . L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice. J Cereb Blood Flow Metab. 1996; 16(4):539-41. DOI: 10.1097/00004647-199607000-00002. View

13.

Vecchione C, Maffei A, Colella S, Aretini A, Poulet R, Frati G . Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes. 2002; 51(1):168-73. DOI: 10.2337/diabetes.51.1.168. View

14.

Tosaka M, Hashiba Y, Saito N, Imai H, Shimizu T, Sasaki T . Contractile responses to reactive oxygen species in the canine basilar artery in vitro: selective inhibitory effect of MCI-186, a new hydroxyl radical scavenger. Acta Neurochir (Wien). 2002; 144(12):1305-10; discussion 1310. DOI: 10.1007/s00701-002-1020-8. View

15.

Didion S, Hathaway C, Faraci F . Superoxide levels and function of cerebral blood vessels after inhibition of CuZn-SOD. Am J Physiol Heart Circ Physiol. 2001; 281(4):H1697-703. DOI: 10.1152/ajpheart.2001.281.4.H1697. View

16.

Erdos B, Snipes J, Miller A, Busija D . Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C. Diabetes. 2004; 53(5):1352-9. DOI: 10.2337/diabetes.53.5.1352. View

17.

Wei E, KONTOS H, Beckman J . Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. Am J Physiol. 1996; 271(3 Pt 2):H1262-6. DOI: 10.1152/ajpheart.1996.271.3.H1262. View

18.

Toda N, Okamura T . The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacol Rev. 2003; 55(2):271-324. DOI: 10.1124/pr.55.2.3. View

19.

Hara H, Waeber C, Huang P, Fujii M, Fishman M, Moskowitz M . Brain distribution of nitric oxide synthase in neuronal or endothelial nitric oxide synthase mutant mice using [3H]L-NG-nitro-arginine autoradiography. Neuroscience. 1996; 75(3):881-90. DOI: 10.1016/0306-4522(96)00313-2. View

20.

Scotland R, Morales-Ruiz M, Chen Y, Yu J, Rudic R, Fulton D . Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res. 2002; 90(8):904-10. DOI: 10.1161/01.res.0000016506.04193.96. View