Some Aspects of the Anemia of Chronic Disorders Modeled and Analyzed by Petri Net Based Approach

Overview

Journal Bioprocess Biosyst Eng

Specialties Biomedical Engineering
Biotechnology

Date 2011 Jan 12

PMID 21221653

Citations 9

Authors

Dorota Formanowicz

Andrea Sackmann

Adam Kozak

Jacek Blazewicz

Piotr Formanowicz

Affiliations

Soon will be listed here.

Abstract

Anemia of chronic disorders is a very important phenomenon and iron is a crucial factor of this complex process. To better understand this process and its influence on some other factors we have built a mathematical model of the human body iron homeostasis, which possibly most exactly would reflect the metabolism of iron in the case of anemia and inflammation. The model has been formulated in the language of Petri net theory, which allows for its simulation and precise analysis. The obtained results of the analysis of the model's behavior, concerning the influence of anemia and inflammation on the transferrin receptors, and hepcidin concentration changes are the valuable complements to the knowledge following from clinical research. This analysis is one of the first attempts to investigate properties and behavior of a not fully understood biological system on a basis of its Petri net based model.

Citing Articles

Pathomechanisms of Disturbances Underlying Chronic Disorders.

Formanowicz D Biomedicines. 2024; 12(1).

PMID: 38255236 PMC: 10813478. DOI: 10.3390/biomedicines12010131.

Modeling and analyzing the action process of monoamine hormones in depression: a Petri nets-based intelligent approach.

Wang X, Yu W, Zhang C, Wang J, Hao F, Li J Front Big Data. 2023; 6:1268503.

PMID: 37817861 PMC: 10561328. DOI: 10.3389/fdata.2023.1268503.

Chronic Kidney Disease as a Cardiovascular Disorder-Tonometry Data Analyses.

Twardawa M, Formanowicz P, Formanowicz D Int J Environ Res Public Health. 2022; 19(19).

PMID: 36231682 PMC: 9566812. DOI: 10.3390/ijerph191912339.

Interrelations between Iron and Vitamin A-Studied Using Systems Approach.

Gutowska K, Formanowicz D, Formanowicz P Int J Mol Sci. 2022; 23(3).

PMID: 35163110 PMC: 8835033. DOI: 10.3390/ijms23031189.

Petri net-based approach to modeling and analysis of selected aspects of the molecular regulation of angiogenesis.

Formanowicz D, Radom M, Zawierucha P, Formanowicz P PLoS One. 2017; 12(3):e0173020.

PMID: 28253310 PMC: 5333880. DOI: 10.1371/journal.pone.0173020.

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