Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and Therapy

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2011 Jan 12

PMID 21221060

Citations 39

Authors

Thomas Schirrmann

Torsten Meyer

Mark Schutte

Andre Frenzel

Michael Hust

Affiliations

Soon will be listed here.

Abstract

Twenty years after its development, antibody phage display using filamentous bacteriophage represents the most successful in vitro antibody selection technology. Initially, its development was encouraged by the unique possibility of directly generating recombinant human antibodies for therapy. Today, antibody phage display has been developed as a robust technology offering great potential for automation. Generation of monospecific binders provides a valuable tool for proteome research, leading to highly enhanced throughput and reduced costs. This review presents the phage display technology, application areas of antibodies in research, diagnostics and therapy and the use of antibody phage display for these applications.

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