Eosinophils Are Required for the Maintenance of Plasma Cells in the Bone Marrow

Overview

Journal Nat Immunol

Date 2011 Jan 11

PMID 21217761

Citations 257

Authors

Van Trung Chu

Anja Frohlich

Gudrun Steinhauser

Tobias Scheel

Toralf Roch

Simon Fillatreau

James J Lee

Max Lohning

Claudia Berek

Affiliations

Soon will be listed here.

Abstract

Plasma cells are of crucial importance for long-term immune protection. It is thought that long-lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate that bone marrow eosinophils localized together with plasma cells and were the key providers of plasma cell survival factors. In vitro, eosinophils supported the survival of plasma cells by secreting the proliferation-inducing ligand APRIL and interleukin-6 (IL-6). In eosinophil-deficient mice, plasma cell numbers were much lower in the bone marrow both at steady state and after immunization. Reconstitution experiments showed that eosinophils were crucial for the retention of plasma cells in the bone marrow. Moreover, depletion of eosinophils induced apoptosis in long-lived bone marrow plasma cells. Our findings demonstrate that the long-term maintenance of plasma cells in the bone marrow requires eosinophils.

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