Canine Specific ELISA for Coagulation Factor VII

Overview

Journal Vet J

Specialty Veterinary Medicine

Date 2011 Jan 11

PMID 21216638

Citations 4

Authors

Tom Knudsen

Mads Kjelgaard-Hansen

Mikael Tranholm

Bo Wiinberg

Jes T Clausen

Jens Jacob Hansen

Timothy C Nichols

Marianne Kjalke

Asger L Jensen

Annemarie T Kristensen

Affiliations

Soon will be listed here.

Abstract

Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been available to date. In this study, a canine specific ELISA for measurement of FVII:Ag in plasma was developed and validated. The FVII:Ag ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVII:C, the FVII:Ag ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency.

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