Lessons from an Anti-DNA Autoantibody

Overview

Journal Mol Immunol

Specialties Allergy & Immunology
Molecular Biology

Date 2011 Jan 11

PMID 21216012

Citations 10

Authors

Joel Cohen-Solal

Betty Diamond

Affiliations

Soon will be listed here.

Abstract

R4A is an anti-DNA antibody derived by hybridoma technology from a BALB/c mouse. The study of its properties has helped to elucidate aspects of the physiopathology of Systemic Lupus Erythematosus (SLE). It has been useful to decipher the mechanisms implicated in breaks in B cell self tolerance by B cell extrinsic or B cell intrinsic factors. Furthermore, it illustrates the importance of molecular mimicry in understanding the cellular and molecular effects relevant to some manifestations of neuropsychiatric lupus, as it cross-reacts with the D/E W D/E YS/G peptide sequence present in subunits of the N-methyl d-aspartate receptor (NMDAR).

Citing Articles

Single-cell approaches to investigate B cells and antibodies in autoimmune neurological disorders.

Zou A, Ramanathan S, Dale R, Brilot F Cell Mol Immunol. 2020; 18(2):294-306.

PMID: 32728203 PMC: 8027387. DOI: 10.1038/s41423-020-0510-z.

Circulating Plasmablasts from Chronically Human Immunodeficiency Virus-Infected Individuals Predominantly Produce Polyreactive/Autoreactive Antibodies.

Liao H, Yu Y, Li S, Yue Y, Tao C, Su K Front Immunol. 2017; 8:1691.

PMID: 29270169 PMC: 5723652. DOI: 10.3389/fimmu.2017.01691.

PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism.

McKay J, Haro M, Daly C, Yammani R, Pang B, Swords W J Immunol. 2017; 199(6):2020-2029.

PMID: 28768724 PMC: 5587397. DOI: 10.4049/jimmunol.1700555.

Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies.

Vanpatten S, Sun S, He M, Cheng K, Altiti A, Papatheodorou A J Med Chem. 2016; 59(19):8859-8867.

PMID: 27603688 PMC: 5592695. DOI: 10.1021/acs.jmedchem.6b00694.

DNA-reactive B cells in lupus.

Suurmond J, Calise J, Malkiel S, Diamond B Curr Opin Immunol. 2016; 43:1-7.

PMID: 27504587 PMC: 5125853. DOI: 10.1016/j.coi.2016.07.002.

References

Venkatesh J, Kawabata D, Kim S, Xu X, Chinnasamy P, Paul E . Selective regulation of autoreactive B cells by FcgammaRIIB. J Autoimmun. 2009; 32(3-4):149-57. PMC: 2688718. DOI: 10.1016/j.jaut.2009.02.009. View

Peeva E, Michael D, Cleary J, Rice J, Chen X, Diamond B . Prolactin modulates the naive B cell repertoire. J Clin Invest. 2003; 111(2):275-83. PMC: 151869. DOI: 10.1172/JCI16530. View

Steup-Beekman G, Steens S, van Buchem M, Huizinga T . Anti-NMDA receptor autoantibodies in patients with systemic lupus erythematosus and their first-degree relatives. Lupus. 2007; 16(5):329-34. DOI: 10.1177/0961203307078224. View

KATZ J, Limpanasithikul W, Diamond B . Mutational analysis of an autoantibody: differential binding and pathogenicity. J Exp Med. 1994; 180(3):925-32. PMC: 2191646. DOI: 10.1084/jem.180.3.925. View

Hanly J, Robichaud J, Fisk J . Anti-NR2 glutamate receptor antibodies and cognitive function in systemic lupus erythematosus. J Rheumatol. 2006; 33(8):1553-8. View

Offen D, Spatz L, Escowitz H, Factor S, Diamond B . Induction of tolerance to an IgG autoantibody. Proc Natl Acad Sci U S A. 1992; 89(17):8332-6. PMC: 49912. DOI: 10.1073/pnas.89.17.8332. View

Sun Y, Fong K, Chung M, Yao Z . Peptide mimicking antigenic and immunogenic epitope of double-stranded DNA in systemic lupus erythematosus. Int Immunol. 2001; 13(2):223-32. DOI: 10.1093/intimm/13.2.223. View

Tsao B, Ohnishi K, Cheroutre H, Mitchell B, Teitell M, Mixter P . Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice. J Immunol. 1992; 149(1):350-8. View

Shefner R, Kleiner G, Turken A, Papazian L, Diamond B . A novel class of anti-DNA antibodies identified in BALB/c mice. J Exp Med. 1991; 173(2):287-96. PMC: 2118791. DOI: 10.1084/jem.173.2.287. View

10.

Wang C, Khalil M, Ravetch J, Diamond B . The naive B cell repertoire predisposes to antigen-induced systemic lupus erythematosus. J Immunol. 2003; 170(9):4826-32. DOI: 10.4049/jimmunol.170.9.4826. View

11.

Faust T, Chang E, Kowal C, Berlin R, Gazaryan I, Bertini E . Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms. Proc Natl Acad Sci U S A. 2010; 107(43):18569-74. PMC: 2972998. DOI: 10.1073/pnas.1006980107. View

12.

Ehrenstein M, Katz D, Griffiths M, Papadaki L, Winkler T, Kalden J . Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int. 1995; 48(3):705-11. DOI: 10.1038/ki.1995.341. View

13.

Satoh M, Chan E, Sobel E, Kimpel D, Yamasaki Y, Narain S . Clinical implication of autoantibodies in patients with systemic rheumatic diseases. Expert Rev Clin Immunol. 2010; 3(5):721-38. DOI: 10.1586/1744666X.3.5.721. View

14.

Ross G, Sammaritano L, Nass R, Lockshin M . Effects of mothers' autoimmune disease during pregnancy on learning disabilities and hand preference in their children. Arch Pediatr Adolesc Med. 2003; 157(4):397-402. DOI: 10.1001/archpedi.157.4.397. View

15.

Kowal C, DeGiorgio L, Lee J, Edgar M, Huerta P, Volpe B . Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci U S A. 2006; 103(52):19854-9. PMC: 1702320. DOI: 10.1073/pnas.0608397104. View

16.

Khalil M, Inaba K, Steinman R, Ravetch J, Diamond B . T cell studies in a peptide-induced model of systemic lupus erythematosus. J Immunol. 2001; 166(3):1667-74. DOI: 10.4049/jimmunol.166.3.1667. View

17.

Lee J, Huerta P, Zhang J, Kowal C, Bertini E, Volpe B . Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus. Nat Med. 2008; 15(1):91-6. PMC: 2615794. DOI: 10.1038/nm.1892. View

18.

Diamond B, Scharff M . Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci U S A. 1984; 81(18):5841-4. PMC: 391807. DOI: 10.1073/pnas.81.18.5841. View

19.

DeGiorgio L, Konstantinov K, Lee S, Hardin J, Volpe B, Diamond B . A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med. 2001; 7(11):1189-93. DOI: 10.1038/nm1101-1189. View

20.

Dieker J, Sun Y, Jacobs C, Putterman C, Monestier M, Muller S . Mimotopes for lupus-derived anti-DNA and nucleosome-specific autoantibodies selected from random peptide phage display libraries: facts and follies. J Immunol Methods. 2005; 296(1-2):83-93. DOI: 10.1016/j.jim.2004.10.010. View