Trichodermanin A, a Novel Diterpenoid from Endophytic Fungus Culture

Overview

Journal J Nat Med

Publisher Springer

Date 2011 Jan 8

PMID 21213064

Citations 9

Authors

Pei-Xin Sun

Cheng-Jian Zheng

Wen-Chao Li

Gui-Lin Jin

Fang Huang

Lu-Ping Qin

Affiliations

Soon will be listed here.

Abstract

Trichodermanin A, a structurally unique diterpenoid with skeletal carbons arranged compactly in a fused 6-5-6-6 ring system, has been isolated from cultures of Trichoderma atroviride (strain no. S361), an endophytic fungus isolate in Cephalotaxus fortunei. The structure of this compound was elucidated based on extensive spectroscopic methods and confirmed by X-ray diffraction analysis.

Citing Articles

Chemistry and biology of marine-derived Trichoderma metabolites.

Song Y, Ji N Nat Prod Bioprospect. 2024; 14(1):14.

PMID: 38302800 PMC: 10834931. DOI: 10.1007/s13659-024-00433-3.

Enantioselective Syntheses of Wickerols A and B.

Chung J, Capani Jr J, Gohl M, Roosen P, Vanderwal C J Am Chem Soc. 2023; 145(11):6486-6497.

PMID: 36883956 PMC: 10037325. DOI: 10.1021/jacs.3c00448.

Trichoderma species from plant and soil: An excellent resource for biosynthesis of terpenoids with versatile bioactivities.

Bai B, Liu C, Zhang C, He X, Wang H, Peng W J Adv Res. 2022; 49:81-102.

PMID: 36195283 PMC: 10334134. DOI: 10.1016/j.jare.2022.09.010.

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010-2020).

Zhang F, Feng T J Fungi (Basel). 2022; 8(3).

PMID: 35330246 PMC: 8951520. DOI: 10.3390/jof8030244.

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies.

Wen J, Okyere S, Wang S, Wang J, Xie L, Ran Y J Fungi (Basel). 2022; 8(2).

PMID: 35205959 PMC: 8877053. DOI: 10.3390/jof8020205.

References

Guo L, Wu J, Han T, Cao T, Rahman K, Qin L . Chemical composition, antifungal and antitumor properties of ether extracts of Scapania verrucosa Heeg. and its endophytic fungus Chaetomium fusiforme. Molecules. 2008; 13(9):2114-25. PMC: 6245190. DOI: 10.3390/molecules13092114. View

Itabashi T, Hosoe T, Wakana D, Fukushima K, Takizawa K, Yaguchi T . A new indoloditerpene derivative, penijanthine A, isolated from Penicillium janthinellum. J Nat Med. 2008; 63(1):96-9. DOI: 10.1007/s11418-008-0292-6. View

Guo L, Huang G, Wang Y, He W, Zheng W, Hyde K . Molecular identification of white morphotype strains of endophytic fungi from Pinus tabulaeformis. Mycol Res. 2003; 107(Pt 6):680-8. DOI: 10.1017/s0953756203007834. View

Xu L, Han T, Wu J, Zhang Q, Zhang H, Huang B . Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus. Phytomedicine. 2009; 16(6-7):609-16. DOI: 10.1016/j.phymed.2009.03.014. View

Strobel G . Endophytes as sources of bioactive products. Microbes Infect. 2003; 5(6):535-44. DOI: 10.1016/s1286-4579(03)00073-x. View