Clinical Characteristics of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART

Overview

Journal Clin Dev Immunol

Specialty Allergy & Immunology

Date 2011 Jan 4

PMID 21197457

Citations 15

Authors

Suman Karmakar

Surendra K Sharma

Richa Vashishtha

Abhishek Sharma

Sanjay Ranjan

Deepak Gupta

Vishnubhatla Sreenivas

Sanjeev Sinha

Ashutosh Biswas

Vinay Gulati

Affiliations

Soon will be listed here.

Abstract

Background & Objective: IRIS is an important complication that occurs during management of HIV-TB coinfection and it poses difficulty in diagnosis. Previous studies have reported variable incidence of IRIS. The present study was undertaken to describe the pattern of TB-associated IRIS using recently proposed consensus case-definitions for TB-IRIS for its use in resource-limited settings.

Methods: A prospective analysis of ART-naïve adults started on HAART from November, 2008 to May, 2010 was done in a tertiary care hospital in north India. A total 224 patients divided into two groups, one with HIV-TB and the other with HIV alone, were followedup for a minimum period of 3 months. The diagnosis of TB was categorised as ''definitive" and ''probable".

Results: Out of a total of 224 patients, 203 completed followup. Paradoxical TB-IRIS occurred in 5 of 123 (4%) HIV-TB patients while 6 of 80 (7.5%) HIV patients developed ART-associated TB. A reduction in plasma viral load was significantly (P = .016) associated with paradoxical TB-IRIS. No identifiable risk factors were associated with the development of ART-associated TB.

Conclusion: The consensus case-definitions are useful tools in the diagnosis of TB-associated IRIS. High index of clinical suspicion is required for an early diagnosis.

Citing Articles

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Types and prevalence of HIV-related opportunistic infections/conditions among HIV-positive patients attending Kenyatta National Hospital in Nairobi, Kenya.

Chepkondol G, Jolly P, Yatich N, Mbowe O, Jaoko W Afr Health Sci. 2020; 20(2):615-624.

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A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome.

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Tuberculosis, human immunodeficiency virus, and the immune reconstitution inflammatory syndrome.

Rapose A, Karande S J Postgrad Med. 2017; 63(4):207-209.

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The Epidemiology of IRIS in Southern India: An Observational Cohort Study.

Thambuchetty N, Mehta K, Arumugam K, Shekarappa U, Idiculla J, Shet A J Int Assoc Provid AIDS Care. 2017; 16(5):475-480.

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