Perinatal Hypoxic-ischemic Encephalopathy

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2011 Jan 4

PMID 21197402

Citations 84

Authors

Ming-Chi Lai

San-Nan Yang

Affiliations

Soon will be listed here.

Abstract

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the newborn and can result in long-term devastating consequences. Perinatal hypoxia is a vital cause of long-term neurologic complications varying from mild behavioural deficits to severe seizure, mental retardation, and/or cerebral palsy in the newborn. In the mammalian developing brain, ongoing research into pathophysiological mechanism of neuronal injury and therapeutic strategy after perinatal hypoxia is still limited. With the advent of promising therapy of hypothermia in HIE, this paper reviews the pathophysiology of HIE and the future potential neuroprotective strategies for clinical potential for hypoxia sufferers.

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