Ethanol Modulation of Synaptic Plasticity

Overview

Journal Neuropharmacology

Specialties Neurology
Pharmacology

Date 2011 Jan 4

PMID 21195719

Citations 63

Authors

Brian A McCool

Affiliations

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Abstract

Synaptic plasticity in the most general terms represents the flexibility of neurotransmission in response to neuronal activity. Synaptic plasticity is essential both for the moment-by-moment modulation of neural activity in response to dynamic environmental cues and for long-term learning and memory formation. These temporal characteristics are served by an array of pre- and post-synaptic mechanisms that are frequently modulated by ethanol exposure. This modulation likely makes significant contributions to both alcohol abuse and dependence. In this review, I discuss the modulation of both short-term and long-term synaptic plasticity in the context of specific ethanol-sensitive cellular substrates. A general discussion of the available preclinical, animal-model based neurophysiology literature provides a comparison between results from in vitro and in vivo studies. Finally, in the context of alcohol abuse and dependence, the review proposes potential behavioral contributions by ethanol modulation of plasticity.

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References

Zhu P, Lovinger D . Ethanol potentiates GABAergic synaptic transmission in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala. J Neurophysiol. 2006; 96(1):433-41. DOI: 10.1152/jn.01380.2005. View

Silberman Y, Shi L, Brunso-Bechtold J, Weiner J . Distinct mechanisms of ethanol potentiation of local and paracapsular GABAergic synapses in the rat basolateral amygdala. J Pharmacol Exp Ther. 2007; 324(1):251-60. DOI: 10.1124/jpet.107.128728. View

Knapp D, Duncan G, Crews F, Breese G . Induction of Fos-like proteins and ultrasonic vocalizations during ethanol withdrawal: further evidence for withdrawal-induced anxiety. Alcohol Clin Exp Res. 1998; 22(2):481-93. View

Roberto M, Nelson T, Ur C, Brunelli M, Sanna P, Gruol D . The transient depression of hippocampal CA1 LTP induced by chronic intermittent ethanol exposure is associated with an inhibition of the MAP kinase pathway. Eur J Neurosci. 2003; 17(8):1646-54. DOI: 10.1046/j.1460-9568.2003.02614.x. View

Kelm M, Criswell H, Breese G . Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Brain Res Rev. 2010; 65(2):113-23. PMC: 3005894. DOI: 10.1016/j.brainresrev.2010.09.003. View

Popp R, Dertien J . Actin depolymerization contributes to ethanol inhibition of NMDA receptors in primary cultured cerebellar granule cells. Alcohol. 2008; 42(7):525-39. PMC: 3244081. DOI: 10.1016/j.alcohol.2008.06.006. View

Swartzwelder H, Wilson W, Tayyeb M . Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. Alcohol Clin Exp Res. 1995; 19(6):1480-5. DOI: 10.1111/j.1530-0277.1995.tb01011.x. View

Ripley T, Little H . Nitrendipine prevents the decrease caused by chronic ethanol intake in the maintenance of tetanic long-term potentiation. Exp Brain Res. 1995; 103(1):1-8. DOI: 10.1007/BF00241959. View

Kelm M, Criswell H, Breese G . Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons. J Pharmacol Exp Ther. 2007; 323(1):356-64. DOI: 10.1124/jpet.107.126144. View

10.

Neher E, Sakaba T . Multiple roles of calcium ions in the regulation of neurotransmitter release. Neuron. 2008; 59(6):861-72. DOI: 10.1016/j.neuron.2008.08.019. View

11.

Morikawa H, Morrisett R . Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. Int Rev Neurobiol. 2010; 91:235-88. PMC: 2936723. DOI: 10.1016/S0074-7742(10)91008-8. View

12.

Olmstead M, Hellemans K, Paine T . Alcohol-induced impulsivity in rats: an effect of cue salience?. Psychopharmacology (Berl). 2005; 184(2):221-8. DOI: 10.1007/s00213-005-0215-0. View

13.

Royer S, Martina M, Pare D . An inhibitory interface gates impulse traffic between the input and output stations of the amygdala. J Neurosci. 1999; 19(23):10575-83. PMC: 6782425. View

14.

Xiao C, Shao X, Olive M, Griffin 3rd W, Li K, Krnjevic K . Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area. Neuropsychopharmacology. 2008; 34(2):307-18. PMC: 2676579. DOI: 10.1038/npp.2008.99. View

15.

Mameli M, Zamudio P, Carta M, Valenzuela C . Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission. J Neurosci. 2005; 25(35):8027-36. PMC: 6725449. DOI: 10.1523/JNEUROSCI.2434-05.2005. View

16.

Braga M, Aroniadou-Anderjaska V, Li H . The physiological role of kainate receptors in the amygdala. Mol Neurobiol. 2004; 30(2):127-41. DOI: 10.1385/MN:30:2:127. View

17.

Stanton P, Sarvey J . Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis. J Neurosci. 1984; 4(12):3080-8. PMC: 6564864. View

18.

Gordon A, Diamond I . Adenosine mediates the effects of ethanol on the cAMP signal transduction system. Alcohol Alcohol Suppl. 1993; 2:437-41. View

19.

Chu H, Yang Z, Zhao B, Jin G, Hu G, Zhen X . Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro. Brain Res. 2010; 1343:20-7. DOI: 10.1016/j.brainres.2010.04.043. View

20.

Weitlauf C, Egli R, Grueter B, Winder D . High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalis. J Neurosci. 2004; 24(25):5741-7. PMC: 6729219. DOI: 10.1523/JNEUROSCI.1181-04.2004. View