Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2010 Dec 31

PMID 21191320

Citations 2

Authors

Marco Martin Gonzalez-Chavez

Francisco Mendez

Roberto Martinez

Cuauhtemoc Perez-Gonzalez

Fidel Martinez-Gutierrez

Affiliations

Soon will be listed here.

Abstract

A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.

Citing Articles

Synthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents.

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Synthesis and antibacterial evaluation of some novel imidazole and benzimidazole sulfonamides.

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