Feed-forward and Feed-backward Amplification Model from Cochlear Cytoarchitecture: an Interspecies Comparison

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2010 Dec 31

PMID 21190651

Citations 47

Authors

Yong-Jin Yoon

Charles R Steele

Sunil Puria

Affiliations

Soon will be listed here.

Abstract

The high sensitivity and wide bandwidth of mammalian hearing are thought to derive from an active process involving the somatic and hair-bundle motility of the thousands of outer hair cells uniquely found in mammalian cochleae. To better understand this, a biophysical three-dimensional cochlear fluid model was developed for gerbil, chinchilla, cat, and human, featuring an active "push-pull" cochlear amplifier mechanism based on the cytoarchitecture of the organ of Corti and using the time-averaged Lagrangian method. Cochlear responses are simulated and compared with in vivo physiological measurements for the basilar membrane (BM) velocity, V(BM), frequency tuning of the BM vibration, and Q₁₀ values representing the sharpness of the cochlear tuning curves. The V(BM) simulation results for gerbil and chinchilla are consistent with in vivo cochlea measurements. Simulated mechanical tuning curves based on maintaining a constant V(BM) value agree with neural-tuning threshold measurements better than those based on a constant displacement value, which implies that the inner hair cells are more sensitive to V(BM) than to BM displacement. The Q₁₀ values of the V(BM) tuning curve agree well with those of cochlear neurons across species, and appear to be related in part to the width of the basilar membrane.

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References

Zwislocki J . Analysis of cochlear mechanics. Hear Res. 1986; 22:155-69. DOI: 10.1016/0378-5955(86)90091-2. View

Naidu R, Mountain D . Basilar membrane tension calculations for the gerbil cochlea. J Acoust Soc Am. 2007; 121(2):994-1002. DOI: 10.1121/1.2404916. View

Brownell W, Bader C, Bertrand D, De Ribaupierre Y . Evoked mechanical responses of isolated cochlear outer hair cells. Science. 1985; 227(4683):194-6. DOI: 10.1126/science.3966153. View

Schmiedt R . Spontaneous rates, thresholds and tuning of auditory-nerve fibers in the gerbil: comparisons to cat data. Hear Res. 1989; 42(1):23-35. DOI: 10.1016/0378-5955(89)90115-9. View

Thorne M, Salt A, DeMott J, Henson M, Henson Jr O, Gewalt S . Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images. Laryngoscope. 1999; 109(10):1661-8. DOI: 10.1097/00005537-199910000-00021. View

Cheatham M, Dallos P . The level dependence of response phase: observations from cochlear hair cells. J Acoust Soc Am. 1998; 104(1):356-69. DOI: 10.1121/1.423245. View

GREENWOOD D . A cochlear frequency-position function for several species--29 years later. J Acoust Soc Am. 1990; 87(6):2592-605. DOI: 10.1121/1.399052. View

Lynch 3rd T, Nedzelnitsky V, PEAKE W . Input impedance of the cochlea in cat. J Acoust Soc Am. 1982; 72(1):108-30. DOI: 10.1121/1.387995. View

Yoon Y, Puria S, Steele C . Intracochlear pressure and derived quantities from a three-dimensional model. J Acoust Soc Am. 2007; 122(2):952-66. DOI: 10.1121/1.2747162. View

10.

Peng A, Ricci A . Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?. Hear Res. 2010; 273(1-2):109-22. PMC: 2943979. DOI: 10.1016/j.heares.2010.03.094. View

11.

Dallos P . Low-frequency auditory characteristics: Species dependence. J Acoust Soc Am. 1970; 48(2):489-99. DOI: 10.1121/1.1912163. View

12.

Steele C, Taber L . Comparison of WKB calculations and experimental results for three-dimensional cochlear models. J Acoust Soc Am. 1979; 65(4):1007-18. DOI: 10.1121/1.382570. View

13.

Aibara R, Welsh J, Puria S, Goode R . Human middle-ear sound transfer function and cochlear input impedance. Hear Res. 2001; 152(1-2):100-9. DOI: 10.1016/s0378-5955(00)00240-9. View

14.

Nam J, Fettiplace R . Force transmission in the organ of Corti micromachine. Biophys J. 2010; 98(12):2813-21. PMC: 2884234. DOI: 10.1016/j.bpj.2010.03.052. View

15.

Ruggero M, Temchin A . Unexceptional sharpness of frequency tuning in the human cochlea. Proc Natl Acad Sci U S A. 2005; 102(51):18614-9. PMC: 1311742. DOI: 10.1073/pnas.0509323102. View

16.

Rhode W . Observations of the vibration of the basilar membrane in squirrel monkeys using the Mössbauer technique. J Acoust Soc Am. 1971; 49(4):Suppl 2:1218+. DOI: 10.1121/1.1912485. View

17.

Sellick P, Patuzzi R, Johnstone B . Measurement of basilar membrane motion in the guinea pig using the Mössbauer technique. J Acoust Soc Am. 1982; 72(1):131-41. DOI: 10.1121/1.387996. View

18.

Edge R, Evans B, Pearce M, Richter C, Hu X, Dallos P . Morphology of the unfixed cochlea. Hear Res. 1998; 124(1-2):1-16. DOI: 10.1016/s0378-5955(98)00090-2. View

19.

Ruggero M, Robles L, Rich N . Cochlear microphonics and the initiation of spikes in the auditory nerve: correlation of single-unit data with neural and receptor potentials recorded from the round window. J Acoust Soc Am. 1986; 79(5):1491-8. DOI: 10.1121/1.393763. View

20.

Olson E . Intracochlear pressure measurements related to cochlear tuning. J Acoust Soc Am. 2001; 110(1):349-67. DOI: 10.1121/1.1369098. View