Genomics and Proteomics in Stem Cell Research: the Road Ahead

Overview

Journal Anat Cell Biol

Specialty Anatomy & Histology

Date 2010 Dec 31

PMID 21190000

Citations 2

Authors

Sung-Min Ahn

Richard Simpson

Bonghee Lee

Affiliations

Soon will be listed here.

Abstract

Stem cell research has been widely studied over the last few years and has attracted increasing attention from researchers in all fields of medicine due to its potential to treat many previously incurable diseases by replacing damaged cells or tissues. As illustrated by hematopoietic stem research, understanding stem cell differentiation at molecular levels is essential for both basic research and for clinical applications of stem cells. Although multiple integrative analyses, such as genomics, epigenomics, transcriptomics and proteomics, are required to understand stem cell biology, proteomics has a unique position in stem cell research. For example, several major breakthroughs in HSC research were due to the identification of proteins such as colony-stimulating factors (CSFs) and cell-surface CD molecules. In 2007, the Human Proteome Organization (HUPO) and the International Society for Stem Cell Research (ISSCR) launched the joint Proteome Biology of Stem Cells Initiative. A systematic proteomics approach to understanding stem cell differentiation will shed new light on stem cell biology and accelerate clinical applications of stem cells.

Citing Articles

Transcriptomics and proteomics in stem cell research.

Wang H, Zhang Q, Fang X Front Med. 2014; 8(4):433-44.

PMID: 24972645 DOI: 10.1007/s11684-014-0336-0.

Expression of surface markers and myogenic potential of rat bone marrow- and adipose-derived stem cells: a comparative study.

Bayati V, Hashemitabar M, Gazor R, Nejatbakhsh R, Bijannejad D Anat Cell Biol. 2013; 46(2):113-21.

PMID: 23869258 PMC: 3713275. DOI: 10.5115/acb.2013.46.2.113.

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