Homocysteine is a Risk Factor in Predialysis Patients when Associated with Malnutrition and Inflammation

Overview

Journal Int J Nephrol

Publisher Wiley

Specialty Nephrology

Date 2010 Dec 29

PMID 21188242

Citations 2

Authors

Ana de Lurdes Agostinho Cabrita Vieira

Alexandre Baptista

Anabela Malho

Ana Pinho

Ana Paula Silva

Idalecio Bernardo

Pedro Leao Neves

Affiliations

Soon will be listed here.

Abstract

The increased level of plasma total homocysteine (tHcy) in chronic kidney disease patients has been reported as a new and independent risk factor for cardiovascular disease. However, after the description of reverse epidemiology in the renal population, the association of tHcy and nutrition became less clear. We evaluated the association between homocysteine, nutritional status, and inflammation, and their impact on mortality in 95 predialysis patients. High sensitivity C-Reactive Protein (hs-CRP), interleukin 6 (IL-6), Tumor Necrosis Factor α (TNF-α)], and tHcy were evaluated, as was the nutritional status by the modified Subjective Global Nutritional Assessment (mSGA). We divided our population in four groups according to their tHcy and mSGA values being above or below the mean level and found the lowest survival in the group with tHcy and mSGA above the mean level, as well as higher levels of IL-6 (P = .03) and TNF-α (P = .045). Higher levels of homocysteine can be associated with higher mortality in predialysis patients, as long as they are associated with malnutrition and inflammation.

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