Gender-specific Genomic Profiling in Metastatic Colorectal Cancer Patients Treated with 5-fluorouracil and Oxaliplatin

Overview

Journal Pharmacogenomics

Specialties Genetics
Pharmacology

Date 2010 Dec 23

PMID 21174620

Citations 7

Authors

Michael A Gordon

Wu Zhang

Dongyun Yang

Syma Iqbal

Anthony El-Khouiery

Fumio Nagashima

Georg Lurje

Melissa Labonte

Peter Wilson

Andy Sherrod

Robert D Ladner

Heinz-Josef Lenz

Affiliations

Soon will be listed here.

Abstract

Aims: Survival and response rates in metastatic colorectal cancer remain poor, despite advances in drug development. There is increasing evidence to suggest that gender-specific differences may contribute to poor clinical outcome. We tested the hypothesis that genomic profiling of metastatic colorectal cancer is dependent on gender.

Materials & Methods: A total of 152 patients with metastatic colorectal cancer who were treated with oxaliplatin and continuous infusion 5-fluorouracil were genotyped for 21 polymorphisms in 13 cancer-related genes by PCR. Classification and regression tree analysis tested for gender-related association of polymorphisms with overall survival, progression-free survival and tumor response.

Results: Classification and regression tree analysis of all polymorphisms, age and race resulted in gender-specific predictors of overall survival, progression-free survival and tumor response. Polymorphisms in the following genes were associated with gender-specific clinical outcome: estrogen receptor β, EGF receptor, xeroderma pigmentosum group D, voltage-gated sodium channel and phospholipase A2.

Conclusion: Genetic profiling to predict the clinical outcome of patients with metastatic colorectal cancer may depend on gender.

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References

Slattery M, Sweeney C, Murtaugh M, Ma K, Wolff R, Potter J . Associations between ERalpha, ERbeta, and AR genotypes and colon and rectal cancer. Cancer Epidemiol Biomarkers Prev. 2005; 14(12):2936-42. DOI: 10.1158/1055-9965.EPI-05-0514. View

Mycielska M, Fraser S, Szatkowski M, Djamgoz M . Contribution of functional voltage-gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: II. Secretory membrane activity. J Cell Physiol. 2003; 195(3):461-9. DOI: 10.1002/jcp.10265. View

Lin J, Pu X, Wang W, Matin S, Tannir N, Wood C . Case-control analysis of nucleotide excision repair pathway and the risk of renal cell carcinoma. Carcinogenesis. 2008; 29(11):2112-9. PMC: 2722861. DOI: 10.1093/carcin/bgn189. View

Xie L, Yu J, Luo H . Expression of estrogen receptor beta in human colorectal cancer. World J Gastroenterol. 2004; 10(2):214-7. PMC: 4717006. DOI: 10.3748/wjg.v10.i2.214. View

Konstantinopoulos P, Kominea A, Vandoros G, Sykiotis G, Andricopoulos P, Varakis I . Oestrogen receptor beta (ERbeta) is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur J Cancer. 2003; 39(9):1251-8. DOI: 10.1016/s0959-8049(03)00239-9. View

Lakhan R, Kumari R, Misra U, Kalita J, Pradhan S, Mittal B . Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population. Br J Clin Pharmacol. 2009; 68(2):214-20. PMC: 2767285. DOI: 10.1111/j.1365-2125.2009.03437.x. View

Martineti V, Picariello L, Tognarini I, Carbonell Sala S, Gozzini A, Azzari C . ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components. Endocr Relat Cancer. 2005; 12(2):455-69. DOI: 10.1677/erc.1.00861. View

Lim S, Cho H, Lee T, Choi C, Min Y, Kim S . Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. Yonsei Med J. 2010; 51(5):692-9. PMC: 2908865. DOI: 10.3349/ymj.2010.51.5.692. View

Buerger H, Gebhardt F, Schmidt H, Beckmann A, Hutmacher K, Simon R . Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression. Cancer Res. 2000; 60(4):854-7. View

10.

Press O, Zhang W, Gordon M, Yang D, Lurje G, Iqbal S . Gender-related survival differences associated with EGFR polymorphisms in metastatic colon cancer. Cancer Res. 2008; 68(8):3037-42. DOI: 10.1158/0008-5472.CAN-07-2718. View

11.

Pullarkat S, Stoehlmacher J, Ghaderi V, Xiong Y, Ingles S, Sherrod A . Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J. 2002; 1(1):65-70. DOI: 10.1038/sj.tpj.6500012. View

12.

Thomas W, Coen N, Faherty S, Flatharta C, Harvey B . Estrogen induces phospholipase A2 activation through ERK1/2 to mobilize intracellular calcium in MCF-7 cells. Steroids. 2005; 71(3):256-65. DOI: 10.1016/j.steroids.2005.10.010. View

13.

Olayioye M, Neve R, Lane H, Hynes N . The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 2000; 19(13):3159-67. PMC: 313958. DOI: 10.1093/emboj/19.13.3159. View

14.

Lossin C . A catalog of SCN1A variants. Brain Dev. 2008; 31(2):114-30. DOI: 10.1016/j.braindev.2008.07.011. View

15.

Eberhart C, Coffey R, Radhika A, Giardiello F, Ferrenbach S, DuBois R . Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology. 1994; 107(4):1183-8. DOI: 10.1016/0016-5085(94)90246-1. View

16.

Jun L, Haiping Z, Beibei Y . Genetic polymorphisms of GSTP1 related to response to 5-FU-oxaliplatin-based chemotherapy and clinical outcome in advanced colorectal cancer patients. Swiss Med Wkly. 2010; 139(49-50):724-8. DOI: 10.4414/smw.2009.12754. View

17.

Weale M, Depondt C, Macdonald S, Smith A, Lai P, Shorvon S . Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping. Am J Hum Genet. 2003; 73(3):551-65. PMC: 1180680. DOI: 10.1086/378098. View

18.

Rubie C, Frick V, Pfeil S, Wagner M, Kollmar O, Kopp B . Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol. 2007; 13(37):4996-5002. PMC: 4434624. DOI: 10.3748/wjg.v13.i37.4996. View

19.

Press O, Zhang W, Gordon M, Yang D, Haiman C, Azuma M . Gender-related survival differences associated with polymorphic variants of estrogen receptor-β (ERβ) in patients with metastatic colon cancer. Pharmacogenomics J. 2010; 11(5):375-82. PMC: 2941547. DOI: 10.1038/tpj.2010.45. View

20.

Grimes J, Fraser S, Stephens G, DOWNING J, Laniado M, Foster C . Differential expression of voltage-activated Na+ currents in two prostatic tumour cell lines: contribution to invasiveness in vitro. FEBS Lett. 1995; 369(2-3):290-4. DOI: 10.1016/0014-5793(95)00772-2. View