Primary Tumor Volume is an Independent Predictor of Outcome Within PT4a-staged Tongue Carcinoma

Overview

Journal Ann Surg Oncol

Publisher Springer

Specialty Oncology

Date 2010 Dec 22

PMID 21174152

Citations 5

Authors

Mu-Kuan Chen

Chih-Ming Chen

Ming-Che Lee

Li-Sheng Chen

Hui-Chuan Chen

Affiliations

Soon will be listed here.

Abstract

Background: We evaluated the heterogeneity of primary tumor volume (PTV) within tumors of the same pT4a-staged tongue carcinoma and to elucidate the effects of PTV on treatment outcomes in patients with pT4a-staged tongue carcinoma.

Methods: Fifty-eight patients with newly diagnosed pT4a-staged tongue carcinoma who received surgery were enrolled onto this study. Magnetic resonance imaging-derived PTV was measured by the summation-of-area technique.

Results: The mean PTV was 24.55 ml, with a range of 5.32 to 119.64 ml. The receiver operating characteristic curve was applied, and the optimal cutoff volume was 23 ml. Large PTV was associated with a significantly poor disease-specific survival (P = 0.010) by the log rank test. The Cox regression model also revealed that large PTV (P = 0.026) and positive lymphatic node metastasis (P = 0.004) were statistically significant in the prognosis of T4a-staged tongue carcinoma.

Conclusions: A substantial variation of PTV was present within the same pT4a-staged tongue carcinoma, and PTV represented an important prognostic factor. In the light of these findings, we suggest that taking the PTV into account in pT4a-staged tongue carcinoma would better refine the newest revised T classification, and the treatment strategies may be different.

Citing Articles

Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma.

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The evolution of nasopharyngeal carcinoma staging.

Guo R, Mao Y, Tang L, Chen L, Sun Y, Ma J Br J Radiol. 2019; 92(1102):20190244.

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Clinical significance of three-dimensional measurement of tumour thickness on magnetic resonance imaging in patients with oral tongue squamous cell carcinoma.

Kwon M, Moon H, Nam S, Lee J, Kim J, Lee Y Eur Radiol. 2015; 26(3):858-65.

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Predicting the Prognosis of Oral Tongue Carcinoma Using a Simple Quantitative Measurement Based on Preoperative MR Imaging: Tumor Thickness versus Tumor Volume.

Hu H, Cheng K, Xu X, Wu F, Tyan Y, Tsai C AJNR Am J Neuroradiol. 2015; 36(7):1338-42.

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Influence of tumor volume on survival in patients with oral squamous cell carcinoma.

Mucke T, Mitchell D, Ritschl L, Tannapfel A, Wolff K, Kesting M J Cancer Res Clin Oncol. 2014; 141(6):1007-11.

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