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An Investigation into the Origin of the Dramatically Reduced Reactivity of Peptide-prolyl-thioesters in Native Chemical Ligation

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Specialty Chemistry
Date 2010 Dec 22
PMID 21173985
Citations 29
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Abstract

The low reactivity of peptide-prolyl-thioesters in native chemical ligation is not due to steric effects at the β-carbon, but rather to the presence of a carbonyl moiety on the nitrogen atom of the proline.

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