Hepatocellular Carcinoma, with Portal Thrombus After Viral Eradication, Disappeared by 5-fluorouracil and Interferon

Overview

Journal World J Hepatol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2010 Dec 22

PMID 21173911

Citations 2

Authors

Tomofumi Miura

Nobuaki Suzuki

Junichiro Nakamura

Satoshi Yamada

Tsutomu Miura

Masahiko Yanagi

Hiroyuki Usuda

Iwao Emura

Toru Takahashi

Affiliations

Soon will be listed here.

Abstract

Hepatocarcinogenesis after a sustained virological response (SVR) in type C chronic hepatitis and cirrhosis is an important issue in endemic areas; hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) therapy is especially very hard. We herein report a first case in which combination therapy with interferon-α and continuous intra-arterial infusion of 5-fluorouracil (designated as FAIT) provided a complete response in HCC with PVTT after SVR. Therefore, we think that FAIT is a good option to treat HCC with or without PVTT, even after SVR.

Citing Articles

Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification.

Xu J, Liu X, Wang S, Wen H World J Surg Oncol. 2015; 13:86.

PMID: 25889711 PMC: 4352541. DOI: 10.1186/s12957-015-0493-x.

Circulating tumor and cancer stem cells in hepatitis C virus-associated liver disease.

Bahnassy A, Zekri A, El-Bastawisy A, Fawzy A, Shetta M, Hussein N World J Gastroenterol. 2015; 20(48):18240-8.

PMID: 25561791 PMC: 4277961. DOI: 10.3748/wjg.v20.i48.18240.

References

Murakami M, Kobayashi S, Marubashi S, Tomimaru Y, Noda T, Wada H . Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2010; 18(2):589-96. DOI: 10.1245/s10434-010-1310-y. View

Noda T, Nagano H, Takemasa I, Yoshioka S, Murakami M, Wada H . Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer. 2009; 100(10):1647-58. PMC: 2696759. DOI: 10.1038/sj.bjc.6605064. View

Obi S, Yoshida H, Toune R, Unuma T, Kanda M, Sato S . Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion. Cancer. 2006; 106(9):1990-7. DOI: 10.1002/cncr.21832. View

Kondo M, Nagano H, Sakon M, Yamamoto H, Morimoto O, Arai I . Expression of interferon alpha/beta receptor in human hepatocellular carcinoma. Int J Oncol. 2000; 17(1):83-8. View

Sakon M, Nagano H, Dono K, Nakamori S, Umeshita K, Yamada A . Combined intraarterial 5-fluorouracil and subcutaneous interferon-alpha therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches. Cancer. 2002; 94(2):435-42. DOI: 10.1002/cncr.10246. View

Nagano H . Treatment of advanced hepatocellular carcinoma: intraarterial infusion chemotherapy combined with interferon. Oncology. 2010; 78 Suppl 1:142-7. DOI: 10.1159/000315243. View

Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Ota H . Hepatic resection followed by IFN-alpha and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch. Hepatogastroenterology. 2007; 54(73):172-9. View

Hirakawa M, Ikeda K, Arase Y, Kawamura Y, Yatsuji H, Hosaka T . Hepatocarcinogenesis following HCV RNA eradication by interferon in chronic hepatitis patients. Intern Med. 2008; 47(19):1637-43. DOI: 10.2169/internalmedicine.47.1087. View

Nishiguchi S, Kuroki T, Nakatani S, Morimoto H, Takeda T, Nakajima S . Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet. 1995; 346(8982):1051-5. DOI: 10.1016/s0140-6736(95)91739-x. View

10.

Benson 3rd A, Abrams T, Ben-Josef E, Bloomston P, Botha J, Clary B . NCCN clinical practice guidelines in oncology: hepatobiliary cancers. J Natl Compr Canc Netw. 2009; 7(4):350-91. PMC: 4461147. DOI: 10.6004/jnccn.2009.0027. View

11.

Wada H, Nagano H, Noda T, Damdinsuren B, Marubashi S, Miyamoto A . Complete remission of hepatocellular carcinoma with portal vein tumor thrombus and lymph node metastases by arterial infusion of 5-fluorouracil and interferon-alpha combination therapy following hepatic resection. J Gastroenterol. 2007; 42(6):501-6. DOI: 10.1007/s00535-007-2028-x. View

12.

Tomimaru Y, Eguchi H, Wada H, Noda T, Murakami M, Kobayashi S . Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells. Br J Cancer. 2010; 102(10):1483-90. PMC: 2869168. DOI: 10.1038/sj.bjc.6605669. View

13.

Nagano H, Miyamoto A, Wada H, Ota H, Marubashi S, Takeda Y . Interferon-alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules. Cancer. 2007; 110(11):2493-501. DOI: 10.1002/cncr.23033. View

14.

Horowitz R, Heerdt B, Hu X, Schwartz E, Wadler S . Combination therapy with 5-fluorouracil and IFN-alpha2a induces a nonrandom increase in DNA fragments of less than 3 megabases in HT29 colon carcinoma cells. Clin Cancer Res. 1997; 3(8):1317-22. View

15.

Ota H, Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T . Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. Br J Cancer. 2005; 93(5):557-64. PMC: 2361594. DOI: 10.1038/sj.bjc.6602742. View

16.

Yoshida H, Arakawa Y, Sata M, Nishiguchi S, Yano M, Fujiyama S . Interferon therapy prolonged life expectancy among chronic hepatitis C patients. Gastroenterology. 2002; 123(2):483-91. DOI: 10.1053/gast.2002.34785. View

17.

Schwartz E, Hoffman M, OConnor C, Wadler S . Stimulation of 5-fluorouracil metabolic activation by interferon-alpha in human colon carcinoma cells. Biochem Biophys Res Commun. 1992; 182(3):1232-9. DOI: 10.1016/0006-291x(92)91863-l. View

18.

Yamamoto T, Nagano H, Imai Y, Fukuda K, Matsumoto H, Kondo M . Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy. Int J Clin Oncol. 2007; 12(2):150-4. DOI: 10.1007/s10147-006-0630-1. View