Aberrant Expression of CKLF-like MARVEL Transmembrane Member 5 (CMTM5) by Promoter Methylation in Myeloid Leukemia

Overview

Journal Leuk Res

Date 2010 Dec 21

PMID 21168207

Citations 17

Authors

Jihong Niu

Henan Li

Yao Zhang

Jinlan Li

Min Xie

Lingdi Li

Xiaoying Qin

Yazhen Qin

Xiaohuan Guo

Qian Jiang

Yanrong Liu

Shanshan Chen

Xiaojun Huang

Wenling Han

Guorui Ruan

Affiliations

Soon will be listed here.

Abstract

CMTM5 has been shown to exhibit tumor suppressor activities, however, its role in leukemia is unclear. Herein we firstly reported the expression and function of CMTM5 in myeloid leukemia. CMTM5 was down-regulated, or undetectable, in leukemia cell lines and bone marrow cells from leukemia patients with promoter methylation. Ectopic expression of CMTM5-v1 strongly inhibited the proliferation of K562 and MEG-01 cells. In addition, significant negative correlations were observed between CMTM5 and three leukemia-specific fusion genes (AML1-ETO, PML-RARα and BCR/ABL1). CMTM5 expression was up-regulated in patients who had undergone treatment. Therefore, CMTM5 may be involved in the pathomechanism of myeloid leukemias.

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