Not Your Usual Cancer Case: Variants of Laryngeal Squamous Cell Carcinoma

Overview

Journal Head Neck Pathol

Specialties Oncology
Pathology

Date 2010 Dec 18

PMID 21165725

Citations 4

Authors

James S Lewis Jr

Affiliations

Soon will be listed here.

Abstract

Although squamous cell carcinoma (SCC) variants account for less than 10% of all laryngeal SCCs, they have many unique biological, morphological, and clinical features. They are also easily confused with other tumor types. Recognition of them is critical for surgical pathologists as is the knowledge of what they mean for the patient. Three of the most common and important of these are basaloid, verrucous, and papillary SCC. These tumor types will be briefly reviewed with a focus on specific controversies, biological questions, and/or recent advancements in our understanding of them.

Citing Articles

Laryngeal malignancies - epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016-July 2020).

Sitaru A, Flondor D, Dinu S, Horhat I, Iftode O, Poenaru M Rom J Morphol Embryol. 2022; 63(1):153-160.

PMID: 36074679 PMC: 9593131. DOI: 10.47162/RJME.63.1.16.

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?.

Lopez F, Williams M, Cardesa A, Hunt J, Strojan P, Rinaldo A Eur Arch Otorhinolaryngol. 2017; 274(7):2709-2726.

PMID: 28364287 DOI: 10.1007/s00405-017-4533-8.

Combined P16 and human papillomavirus testing predicts head and neck cancer survival.

Salazar C, Anayannis N, Smith R, Wang Y, Haigentz Jr M, Garg M Int J Cancer. 2014; 135(10):2404-12.

PMID: 24706381 PMC: 4159440. DOI: 10.1002/ijc.28876.

Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: what do we know now that we did not know a decade ago?.

Devaney K, Ferlito A, Rinaldo A, El-Naggar A, Barnes L Eur Arch Otorhinolaryngol. 2011; 268(4):477-80.

PMID: 21286737 DOI: 10.1007/s00405-011-1495-0.

References

Begum S, Westra W . Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008; 32(7):1044-50. DOI: 10.1097/PAS.0b013e31816380ec. View

Ishiyama A, Eversole L, Ross D, Raz Y, Kerner M, Fu Y . Papillary squamous neoplasms of the head and neck. Laryngoscope. 1994; 104(12):1446-52. DOI: 10.1288/00005537-199412000-00004. View

Suarez P, Adler-Storthz K, Luna M, El-Naggar A, Abdul-Karim F, BATSAKIS J . Papillary squamous cell carcinomas of the upper aerodigestive tract: a clinicopathologic and molecular study. Head Neck. 2000; 22(4):360-8. DOI: 10.1002/1097-0347(200007)22:4<360::aid-hed8>3.0.co;2-w. View

Jo V, Mills S, Stoler M, Stelow E . Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009; 33(11):1720-4. DOI: 10.1097/PAS.0b013e3181b6d8e6. View

Serrano M, El-Mofty S, Gnepp D, Lewis Jr J . Utility of high molecular weight cytokeratins, but not p63, in the differential diagnosis of neuroendocrine and basaloid carcinomas of the head and neck. Hum Pathol. 2008; 39(4):591-8. DOI: 10.1016/j.humpath.2007.08.019. View

Chernock R, El-Mofty S, Thorstad W, Parvin C, Lewis Jr J . HPV-related nonkeratinizing squamous cell carcinoma of the oropharynx: utility of microscopic features in predicting patient outcome. Head Neck Pathol. 2010; 3(3):186-94. PMC: 2811624. DOI: 10.1007/s12105-009-0126-1. View

Chernock R, Lewis Jr J, Zhang Q, El-Mofty S . Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. Hum Pathol. 2010; 41(7):1016-23. PMC: 3873737. DOI: 10.1016/j.humpath.2009.11.015. View

Wain S, Kier R, Vollmer R, Bossen E . Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: report of 10 cases. Hum Pathol. 1986; 17(11):1158-66. DOI: 10.1016/s0046-8177(86)80422-1. View

Thompson L, Wenig B, Heffner D, Gnepp D . Exophytic and papillary squamous cell carcinomas of the larynx: A clinicopathologic series of 104 cases. Otolaryngol Head Neck Surg. 1999; 120(5):718-24. DOI: 10.1053/hn.1999.v120.a92773. View

10.

Steffen C . The man behind the eponym: Lauren V. Ackerman and verrucous carcinoma of Ackerman. Am J Dermatopathol. 2004; 26(4):334-41. DOI: 10.1097/00000372-200408000-00009. View

11.

Koch B, Trask D, Hoffman H, Karnell L, Robinson R, Zhen W . National survey of head and neck verrucous carcinoma: patterns of presentation, care, and outcome. Cancer. 2001; 92(1):110-20. DOI: 10.1002/1097-0142(20010701)92:1<110::aid-cncr1298>3.0.co;2-k. View

12.

Cobo F, Talavera P, Concha A . Review article: relationship of human papillomavirus with papillary squamous cell carcinoma of the upper aerodigestive tract: a review. Int J Surg Pathol. 2008; 16(2):127-36. DOI: 10.1177/1066896908314700. View

13.

Syrjanen S . Human papillomavirus (HPV) in head and neck cancer. J Clin Virol. 2005; 32 Suppl 1:S59-66. DOI: 10.1016/j.jcv.2004.11.017. View

14.

Orvidas L, Olsen K, Lewis J, Suman V . Verrucous carcinoma of the larynx: a review of 53 patients. Head Neck. 1998; 20(3):197-203. DOI: 10.1002/(sici)1097-0347(199805)20:3<197::aid-hed3>3.0.co;2-w. View

15.

Calhoun K, Fulmer P, Weiss R, Hokanson J . Distant metastases from head and neck squamous cell carcinomas. Laryngoscope. 1994; 104(10):1199-205. DOI: 10.1288/00005537-199410000-00003. View

16.

Ferlito A, Recher G . Ackerman's tumor (verrucous carcinoma) of the larynx: a clinicopathologic study of 77 cases. Cancer. 1980; 46(7):1617-30. DOI: 10.1002/1097-0142(19801001)46:7<1617::aid-cncr2820460722>3.0.co;2-t. View

17.

Morice W, Ferreiro J . Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. Hum Pathol. 1998; 29(6):609-12. DOI: 10.1016/s0046-8177(98)80011-7. View

18.

Saito T, Nakajima T, Mogi K . Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and precancer with special reference to verrucous carcinomas. J Oral Pathol Med. 1999; 28(5):226-32. DOI: 10.1111/j.1600-0714.1999.tb02029.x. View

19.

Skarsgard D, Groome P, Mackillop W, Zhou S, ROTHWELL D, Dixon P . Cancers of the upper aerodigestive tract in Ontario, Canada, and the United States. Cancer. 2000; 88(7):1728-38. DOI: 10.1002/(sici)1097-0142(20000401)88:7<1728::aid-cncr29>3.0.co;2-7. View

20.

Soriano E, Faure C, Lantuejoul S, Reyt E, Bolla M, Brambilla E . Course and prognosis of basaloid squamous cell carcinoma of the head and neck: a case-control study of 62 patients. Eur J Cancer. 2007; 44(2):244-50. DOI: 10.1016/j.ejca.2007.11.008. View