Esophagitis Dissecans Superficialis and Autoimmune Bullous Dermatoses: A Review

Overview

Journal World J Gastrointest Endosc

Publisher Baishideng Publishing Group

Date 2010 Dec 17

PMID 21160615

Citations 19

Authors

Akira Hokama

Yu-Ichi Yamamoto

Kiyohito Taira

Mitsuteru Nakamura

Chiharu Kobashigawa

Manabu Nakamoto

Tetsuo Hirata

Nagisa Kinjo

Fukunori Kinjo

Kenzo Takahashi

Jiro Fujita

Affiliations

Soon will be listed here.

Abstract

Esophagitis dissecans superficialis (EDS) is a rare and severe endoscopic finding characterized by sloughing of large fragments of esophageal mucosal lining. Although EDS has been reported in association with serious illnesses and certain medications, the pathophysiological association of autoimmune bullous dermatoses with EDS has gained remarkable attention. Among these dermatoses, pemphigus vulgaris and pemphigoid frequently present with various types of esophageal involvement including EDS. We review the pathophysiology and clinical features of this involvement with the presentation of our experiences. The importance of endoscopic evaluation of this entity is discussed.

Citing Articles

Esophagitis Dissecans Superficialis: Unveiling the Enigmatic Entity of Esophageal Mucosal Sloughing.

Qasim A, Jyala A, Ghazanfar H, Baqui A, Patel H Cureus. 2023; 15(8):e43549.

PMID: 37719494 PMC: 10502395. DOI: 10.7759/cureus.43549.

Esophageal Stricture Recalcitrant to Repeated Dilation in Complex Rheumatological Disease.

Olson C, Vora H, Kroner P, Pang M ACG Case Rep J. 2023; 9(12):e00940.

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Esophageal lichen planus: Current knowledge, challenges and future perspectives.

Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt A, Schmitt-Graeff A World J Gastroenterol. 2022; 28(41):5893-5909.

PMID: 36405107 PMC: 9669830. DOI: 10.3748/wjg.v28.i41.5893.

Regurgitation and prolapse of oesophageal mucosa: a dramatic presentation of the oesophagitis dissecans superficialis.

Shaikh O, Gaur N, Vijayakumar C, Kumbhar U BMJ Case Rep. 2022; 15(3).

PMID: 35318207 PMC: 8943745. DOI: 10.1136/bcr-2022-249006.

[Pemphigus vulgaris with exclusive affectation in the esophagus: a case report].

Maldonado-Paredes S, Juarez-Cedillo T, Godinez-Escobar K, Contreras-Rodriguez Y, Gallegos-De Luna C, Alanis-Ocadiz A Rev Med Inst Mex Seguro Soc. 2022; 60(1):75-79.

PMID: 35274914 PMC: 10395950.

References

Galloro G, Diamantis G, Magno L, Inzirillo M, Mignogna M, Mignogna C . Technical aspects in endoscopic biopsy of lesions in esophageal pemphigus vulgaris. Dig Liver Dis. 2007; 39(4):363-7. DOI: 10.1016/j.dld.2006.12.008. View

Ostlere L, Mallet R, Howard P, Holden C . Oesophageal webs associated with cicatricial pemphigoid. Clin Exp Dermatol. 1995; 20(2):176-7. DOI: 10.1111/j.1365-2230.1995.tb02680.x. View

Lever W . Pemphigus. Medicine (Baltimore). 1953; 32(1):1-123. DOI: 10.1097/00005792-195302000-00001. View

Robles I, Saenz R . Esophagitis dissecans presenting with halitosis. Endoscopy. 2010; 42 Suppl 2:E21. DOI: 10.1055/s-0029-1215365. View

Kleber G, Hack M, Goebeler M . Dysphagia as a clue to mucous membrane pemphigoid. Clin Gastroenterol Hepatol. 2006; 4(2):xxiv. DOI: 10.1016/j.cgh.2005.10.009. View

Revuz J . Oesophageal involvement in pemphigus vulgaris. Lancet. 2000; 355(9204):656. DOI: 10.1016/S0140-6736(05)72395-3. View

Sharon P, Greene M, Rachmilewitz D . Esophageal involvement in bullous pemphigoid. Gastrointest Endosc. 1978; 24(3):122-3. DOI: 10.1016/s0016-5107(78)73479-6. View

Monkemuller K, Neumann H, Fry L . Esophageal blebs and blisters. Gastroenterology. 2009; 138(2):e3-4. DOI: 10.1053/j.gastro.2009.05.068. View

Kaneko F, Mori M, Tsukinaga I, Miura Y . Pemphigus vulgaris of esophageal mucosa. Arch Dermatol. 1985; 121(2):272-3. View

10.

Sallout H, Anhalt G, Al-Kawas F . Mucous membrane pemphigoid presenting with isolated esophageal involvement: a case report. Gastrointest Endosc. 2000; 52(3):429-33. DOI: 10.1067/mge.2000.108295. View

11.

Barnes L, Clark M, Estes S, Bongiovanni G . Pemphigus vulgaris involving the esophagus. A case report and review of the literature. Dig Dis Sci. 1987; 32(6):655-9. DOI: 10.1007/BF01296167. View

12.

Galloro G, Mignogna M, de Werra C, Magno L, Diamantis G, Ruoppo E . The role of upper endoscopy in identifying oesophageal involvement in patients with oral pemphigus vulgaris. Dig Liver Dis. 2005; 37(3):195-9. DOI: 10.1016/j.dld.2004.10.005. View

13.

Hage-Nassar G, Rotterdam H, Frank D, Green P . Esophagitis dissecans superficialis associated with celiac disease. Gastrointest Endosc. 2003; 57(1):140-1. DOI: 10.1067/mge.2003.42. View

14.

Bystryn J, Rudolph J . Pemphigus. Lancet. 2005; 366(9479):61-73. DOI: 10.1016/S0140-6736(05)66829-8. View

15.

Venkataram M, Ramakrishna B, Al-Hilli F . Relapse of pemphigus vulgaris presenting with haematemesis. Dermatology. 2001; 203(1):85-6. DOI: 10.1159/000051715. View

16.

Femiano F . Pemphigus vulgaris: recent advances in our understanding of its pathogenesis. Minerva Stomatol. 2007; 56(4):215-23. View

17.

Park J, Chun H, Jeen Y, Lee H, Um S, Lee S . Esophageal cicatricial pemphigoid. Gastrointest Endosc. 2002; 55(7):909. DOI: 10.1067/mge.2002.121800. View

18.

Trattner A, Lurie R, Leiser A, David M, Hazaz B, KADISH U . Esophageal involvement in pemphigus vulgaris: a clinical, histologic, and immunopathologic study. J Am Acad Dermatol. 1991; 24(2 Pt 1):223-6. DOI: 10.1016/0190-9622(91)70031-v. View

19.

Chong V, Lim C, Vu C . A rare cause of acute upper gastrointestinal bleeding. Surg Laparosc Endosc Percutan Tech. 2006; 16(2):91-3. DOI: 10.1097/00129689-200604000-00007. View

20.

Coelho L, Troncon L, Roselino A, Campos M, Modena J . Esophageal Nikolsky's sign in pemphigus vulgaris. Endoscopy. 1997; 29(7):S35. DOI: 10.1055/s-2007-1004283. View