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Dimensions of the Foveal Avascular Zone Using the Heidelberg Retinal Angiogram-2 in Normal Eyes

Overview
Specialty Ophthalmology
Date 2010 Dec 16
PMID 21157065
Citations 15
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Abstract

Purpose: The purpose was to study the dimensions of the foveal avascular zone (FAZ) using Heidelberg Retinal Angiogram-2 (HRA-2; Heidelberg Engineering GmBH, Dossenheim, Germany).

Materials And Methods: An observational study of the FAZ area and circumference was done with fundus fluorescein angiography (FFA) using HRA-2 in 31 normal individuals. The FAZ was studied using both contrast-adjusted and nonadjusted methods. Contrast adjustment was done to obtain better visualization of the finer capillaries around the fovea enabling more precise measurements of the FAZ in normal eyes.

Results: The mean area of the FAZ calculated by the contrast-adjusted method was 0.2753 mm 2 (±0.074) and the mean circumference was 2.22 mm (±0.048). By the conventional method, the area and circumference of the FAZ were 0.6241 mm 2 (±0.177) and 3.23 mm (±0.454), respectively.

Conclusion: The measurements of area and circumference of FAZ using contrast-adjusted methods were significantly smaller than the conventional method.

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References
1.
Wolf S, Arend O, Toonen H, Bertram B, Jung F, Reim M . Retinal capillary blood flow measurement with a scanning laser ophthalmoscope. Preliminary results. Ophthalmology. 1991; 98(6):996-1000. DOI: 10.1016/s0161-6420(91)32192-4. View

2.
Bresnick G, Condit R, Syrjala S, Palta M, Groo A, Korth K . Abnormalities of the foveal avascular zone in diabetic retinopathy. Arch Ophthalmol. 1984; 102(9):1286-93. DOI: 10.1001/archopht.1984.01040031036019. View

3.
Arend O, Wolf S, Harris A, Reim M . The relationship of macular microcirculation to visual acuity in diabetic patients. Arch Ophthalmol. 1995; 113(5):610-4. DOI: 10.1001/archopht.1995.01100050078034. View

4.
Mansour A, Schachat A, Bodiford G, Haymond R . Foveal avascular zone in diabetes mellitus. Retina. 1993; 13(2):125-8. DOI: 10.1097/00006982-199313020-00006. View