Antiepileptic Drugs in Pregnancy and Hemorrhagic Disease of the Newborn: an Update

Overview

Journal Can Fam Physician

Specialties General Medicine
Public Health

Date 2010 Dec 16

PMID 21156891

Citations 2

Authors

Aleksey Kazmin

Renee C Wong

Mathew Sermer

Gideon Koren

Affiliations

Soon will be listed here.

Abstract

Question: What is the current evidence regarding the association between hemorrhagic disease of the newborn and maternal use of hepatic enzyme-inducing antiepileptic drugs (eg, carbamazepine, phenobarbitone, topiramate)?

Answer: Women with epilepsy who take enzyme-inducing antiepileptic drugs should be advised that there is no adequate evidence to support or refute taking vitamin K in late pregnancy to prevent bleeding complications in a newborn.

Citing Articles

Vitamin K supplementation during pregnancy for improving outcomes: a systematic review and meta-analysis.

Shahrook S, Ota E, Hanada N, Sawada K, Mori R Sci Rep. 2018; 8(1):11459.

PMID: 30061633 PMC: 6065418. DOI: 10.1038/s41598-018-29616-y.

Treatment of bipolar disorders during pregnancy: maternal and fetal safety and challenges.

Epstein R, Moore K, Bobo W Drug Healthc Patient Saf. 2015; 7:7-29.

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