A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.
Citing Articles
Assessing vaccine effectiveness for varicella in Wuxi, China: a time-series analysis.
Wang L, Yang X, Wang X, Shi P, Zhang X
Ann Med. 2023; 55(2):2246369.
PMID: 37585612
PMC: 10434998.
DOI: 10.1080/07853890.2023.2246369.
Vaccines for measles, mumps, rubella, and varicella in children.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini M, Demicheli V
Cochrane Database Syst Rev. 2021; 11:CD004407.
PMID: 34806766
PMC: 8607336.
DOI: 10.1002/14651858.CD004407.pub5.
Assessing the vaccine effectiveness for hand, foot, and mouth disease in Guangzhou, China: a time-series analysis.
Du Z, Huang Y, Bloom M, Zhang Z, Yang Z, Lu J
Hum Vaccin Immunother. 2020; 17(1):217-223.
PMID: 32530733
PMC: 7872061.
DOI: 10.1080/21645515.2020.1763076.
Vaccines for measles, mumps, rubella, and varicella in children.
Di Pietrantonj C, Rivetti A, Marchione P, Debalini M, Demicheli V
Cochrane Database Syst Rev. 2020; 4:CD004407.
PMID: 32309885
PMC: 7169657.
DOI: 10.1002/14651858.CD004407.pub4.
Varicella vaccination - the global experience.
Wutzler P, Bonanni P, Burgess M, Gershon A, Safadi M, Casabona G
Expert Rev Vaccines. 2017; 16(8):833-843.
PMID: 28644696
PMC: 5739310.
DOI: 10.1080/14760584.2017.1343669.
Assessing varicella vaccine effectiveness and its influencing factors using health insurance claims data, Germany, 2006 to 2015.
Rieck T, Feig M, An der Heiden M, Siedler A, Wichmann O
Euro Surveill. 2017; 22(17).
PMID: 28488996
PMC: 5434885.
DOI: 10.2807/1560-7917.ES.2017.22.17.30521.
Bayesian penalized spline models for the analysis of spatio-temporal count data.
Bauer C, Wakefield J, Rue H, Self S, Feng Z, Wang Y
Stat Med. 2015; 35(11):1848-65.
PMID: 26530705
PMC: 4959802.
DOI: 10.1002/sim.6785.
Modelling Hospitalisation Ratios for Febrile Convulsions and Severe Varicella Under Combined Measles, Mumps, Rubella, and Varicella (MMRV-Priorix-Tetra™) Compared to Separate MMR + V Vaccination.
Bauchau V, Van Holle L, Cohen C
Drug Saf. 2015; 38(11):1095-102.
PMID: 26251259
PMC: 4608986.
DOI: 10.1007/s40264-015-0326-4.
Effectiveness of vaccination against varicella in children under 5 years in Puglia, Italy 2006-2012.
Tafuri S, Fortunato F, Cappelli M, Cozza V, Bechini A, Bonanni P
Hum Vaccin Immunother. 2014; 11(1):214-9.
PMID: 25483538
PMC: 4514359.
DOI: 10.4161/hv.36153.
The complementary roles of Phase 3 trials and post-licensure surveillance in the evaluation of new vaccines.
Lopalco P, DeStefano F
Vaccine. 2014; 33(13):1541-8.
PMID: 25444788
PMC: 4596394.
DOI: 10.1016/j.vaccine.2014.10.047.
Successes and challenges in varicella vaccine.
Papaloukas O, Giannouli G, Papaevangelou V
Ther Adv Vaccines. 2014; 2(2):39-55.
PMID: 24757524
PMC: 3991154.
DOI: 10.1177/2051013613515621.
Disease burden of herpes zoster in Sweden--predominance in the elderly and in women - a register based study.
Studahl M, Petzold M, Cassel T
BMC Infect Dis. 2013; 13:586.
PMID: 24330510
PMC: 3866924.
DOI: 10.1186/1471-2334-13-586.
Varicella routine vaccination and the effects on varicella epidemiology - results from the Bavarian Varicella Surveillance Project (BaVariPro), 2006-2011.
Streng A, Grote V, Carr D, Hagemann C, Liese J
BMC Infect Dis. 2013; 13:303.
PMID: 23815523
PMC: 3710078.
DOI: 10.1186/1471-2334-13-303.
