Clinical and Molecular Insights into Tuberous Sclerosis Complex Renal Disease

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2010 Dec 15

PMID 21152937

Citations 18

Authors

Brian J Siroky

Hong Yin

John J Bissler

Affiliations

Soon will be listed here.

Abstract

Patients with tuberous sclerosis complex are at great risk of developing renal lesions as part of their disease. These lesions include renal cysts and tumors. Significant advances in understanding the cell biology of these renal lesions has already led to clinical trials demonstrating that pharmacological interventions are likely possible. This review focuses on the pathology of these renal lesions, their underlying cell biology, and the possible therapeutic strategies that may prove to significantly improve care for these patients.

Citing Articles

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Arginine depletion attenuates renal cystogenesis in tuberous sclerosis complex model.

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Benign Renal Tumors in Pediatric Age Group: Retrospective Analysis.

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