Treatment of Chronic Hepatitis C Virus Infection in Dialysis Patients: an Update

Overview

Journal Hepat Res Treat

Date 2010 Dec 15

PMID 21152180

Citations 4

Authors

Hugo Weclawiak

Nassim Kamar

Abdellatif Ould-Mohamed

Isabelle Cardeau-Desangles

Jacques Izopet

Lionel Rostaing

Affiliations

Soon will be listed here.

Abstract

Hepatitis C virus (HCV) infection is a blood-borne infection and its prevalence used to be elevated in hemodialysis (HD) patients. Its main mode of contamination relies on nosocomial transmission. HCV infection is frequently associated in HD patients with normal liver enzymes whereas liver histology can display some degree of HCV-related lesions. The assessment of HCV-related lesions, even in HD dialysis patients, can be done via noninvasive tests. After kidney transplantation, HCV-related lesions can worsen; however, in this setting antiviral treatment harbors the risk of acute rejection. Therefore, it is recommended to implement antiviral treatment while the patient is receiving dialysis therapy. In this setting, the rate of viral clearance is usually high. In case of sustained virological response, no relapse occurs after kidney transplantation, despite heavy immunosuppression.

Citing Articles

Differential Effect of Viral Hepatitis Infection on Mortality among Korean Maintenance Dialysis Patients: A Prospective Multicenter Cohort Study.

Kwon E, Cho J, Jang H, Kim Y, Kang S, Yang C PLoS One. 2015; 10(8):e0135476.

PMID: 26263373 PMC: 4532453. DOI: 10.1371/journal.pone.0135476.

Hepatitis C infection in hemodialysis patients: A review.

Etik D, Ocal S, Boyacioglu A World J Hepatol. 2015; 7(6):885-95.

PMID: 25937865 PMC: 4411530. DOI: 10.4254/wjh.v7.i6.885.

Treatment of HCV patients before and after renal transplantation.

Du L, Tang H Hepat Mon. 2012; 11(11):880-6.

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Management of the kidney transplant patient with chronic hepatitis C infection.

Tang I, Walzer N, Aggarwal N, Tzvetanov I, Cotler S, Benedetti E Int J Nephrol. 2011; 2011:245823.

PMID: 21603155 PMC: 3096939. DOI: 10.4061/2011/245823.

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