Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas

Overview

Journal Patholog Res Int

Publisher Hindawi

Specialty Pathology

Date 2010 Dec 15

PMID 21151538

Citations 4

Authors

Tibor Tot

Gyula Pekar

Syster Hofmeyer

Maria Gere

Miklos Tarjan

Dan Hellberg

David Lindquist

Affiliations

Soon will be listed here.

Abstract

We analyzed the subgross distribution of the invasive component in 875 consecutive cases of breast carcinomas using large-format histology sections and compared the immunophenotype (estrogen and progesterone receptor expression, HER2 overexpression and expression of basal-like markers, CK5/6, CK14, and epidermal growth factor receptor) in unifocal, multifocal, and diffuse tumors. Histology grade and lymph node status were also analyzed. Unifocal invasive carcinomas comprised 58.6% (513/875), multifocal invasive carcinomas 36.5% (319/875), and diffuse invasive carcinomas 4.9% (43/875) of the cases. The proportion of lymph node-positive cases was significantly higher in multifocal and diffuse carcinomas compared to unifocal cancers, but no other statistically significant differences could be verified between these tumor categories. Histological multifocality and diffuse distribution of the invasive tumor component seem to be negative morphologic prognostic parameters in breast carcinomas, independent of the molecular phenotype.

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