Auditory Cortex Spatial Sensitivity Sharpens During Task Performance

Overview

Journal Nat Neurosci

Date 2010 Dec 15

PMID 21151120

Citations 91

Authors

Chen-Chung Lee

John C Middlebrooks

Affiliations

Soon will be listed here.

Abstract

Activity in the primary auditory cortex (A1) is essential for normal sound localization behavior, but previous studies of the spatial sensitivity of neurons in A1 have found broad spatial tuning. We tested the hypothesis that spatial tuning sharpens when an animal engages in an auditory task. Cats performed a task that required evaluation of the locations of sounds and one that required active listening, but in which sound location was irrelevant. Some 26-44% of the units recorded in A1 showed substantially sharpened spatial tuning during the behavioral tasks as compared with idle conditions, with the greatest sharpening occurring during the location-relevant task. Spatial sharpening occurred on a scale of tens of seconds and could be replicated multiple times in ∼1.5-h test sessions. Sharpening resulted primarily from increased suppression of responses to sounds at least-preferred locations. That and an observed increase in latencies suggest an important role of inhibitory mechanisms.

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References

Diamond D, Weinberger N . Role of context in the expression of learning-induced plasticity of single neurons in auditory cortex. Behav Neurosci. 1989; 103(3):471-94. DOI: 10.1037//0735-7044.103.3.471. View

Rasmusson D, Smith S, Semba K . Inactivation of prefrontal cortex abolishes cortical acetylcholine release evoked by sensory or sensory pathway stimulation in the rat. Neuroscience. 2007; 149(1):232-41. DOI: 10.1016/j.neuroscience.2007.06.057. View

Kidd Jr G, Arbogast T, Mason C, Gallun F . The advantage of knowing where to listen. J Acoust Soc Am. 2006; 118(6):3804-15. DOI: 10.1121/1.2109187. View

Allen K, Alais D, Carlile S . Speech intelligibility reduces over distance from an attended location: evidence for an auditory spatial gradient of attention. Atten Percept Psychophys. 2009; 71(1):164-73. DOI: 10.3758/APP.71.1.164. View

Otazu G, Tai L, Yang Y, Zador A . Engaging in an auditory task suppresses responses in auditory cortex. Nat Neurosci. 2009; 12(5):646-54. PMC: 4084972. DOI: 10.1038/nn.2306. View

Witte R, Kipke D . Enhanced contrast sensitivity in auditory cortex as cats learn to discriminate sound frequencies. Brain Res Cogn Brain Res. 2005; 23(2-3):171-84. DOI: 10.1016/j.cogbrainres.2004.10.018. View

Ter-Mikaelian M, Sanes D, Semple M . Transformation of temporal properties between auditory midbrain and cortex in the awake Mongolian gerbil. J Neurosci. 2007; 27(23):6091-102. PMC: 6672143. DOI: 10.1523/JNEUROSCI.4848-06.2007. View

Kimura A, Imbe H, Donishi T, Tamai Y . Axonal projections of single auditory neurons in the thalamic reticular nucleus: implications for tonotopy-related gating function and cross-modal modulation. Eur J Neurosci. 2007; 26(12):3524-35. DOI: 10.1111/j.1460-9568.2007.05925.x. View

McAlonan K, Cavanaugh J, Wurtz R . Attentional modulation of thalamic reticular neurons. J Neurosci. 2006; 26(16):4444-50. PMC: 6674014. DOI: 10.1523/JNEUROSCI.5602-05.2006. View

10.

Nunamaker E, Purcell E, Kipke D . In vivo stability and biocompatibility of implanted calcium alginate disks. J Biomed Mater Res A. 2007; 83(4):1128-1137. DOI: 10.1002/jbm.a.31275. View

11.

Mondor T, Zatorre R . Shifting and focusing auditory spatial attention. J Exp Psychol Hum Percept Perform. 1995; 21(2):387-409. DOI: 10.1037//0096-1523.21.2.387. View

12.

Polley D, Steinberg E, Merzenich M . Perceptual learning directs auditory cortical map reorganization through top-down influences. J Neurosci. 2006; 26(18):4970-82. PMC: 6674159. DOI: 10.1523/JNEUROSCI.3771-05.2006. View

13.

Mickey B, Middlebrooks J . Representation of auditory space by cortical neurons in awake cats. J Neurosci. 2003; 23(25):8649-63. PMC: 6740412. View

14.

Ohl F, Scheich H . Learning-induced plasticity in animal and human auditory cortex. Curr Opin Neurobiol. 2005; 15(4):470-7. DOI: 10.1016/j.conb.2005.07.002. View

15.

Cotillon-Williams N, Huetz C, Hennevin E, Edeline J . Tonotopic control of auditory thalamus frequency tuning by reticular thalamic neurons. J Neurophysiol. 2007; 99(3):1137-51. DOI: 10.1152/jn.01159.2007. View

16.

Zhang Y, Yan J . Corticothalamic feedback for sound-specific plasticity of auditory thalamic neurons elicited by tones paired with basal forebrain stimulation. Cereb Cortex. 2008; 18(7):1521-8. DOI: 10.1093/cercor/bhm188. View

17.

Rhodes G . Auditory attention and the representation of spatial information. Percept Psychophys. 1987; 42(1):1-14. DOI: 10.3758/bf03211508. View

18.

Imig T, Irons W, Samson F . Single-unit selectivity to azimuthal direction and sound pressure level of noise bursts in cat high-frequency primary auditory cortex. J Neurophysiol. 1990; 63(6):1448-66. DOI: 10.1152/jn.1990.63.6.1448. View

19.

Stecker G, Harrington I, Macpherson E, Middlebrooks J . Spatial sensitivity in the dorsal zone (area DZ) of cat auditory cortex. J Neurophysiol. 2005; 94(2):1267-80. DOI: 10.1152/jn.00104.2005. View

20.

Bao S, Chan V, Merzenich M . Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Nature. 2001; 412(6842):79-83. DOI: 10.1038/35083586. View